B2T3X3 · ISPF_PARPJ

Function

function

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site10a divalent metal cation (UniProtKB | ChEBI)
Binding site10-124-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site12a divalent metal cation (UniProtKB | ChEBI)
Site36Transition state stabilizer
Binding site36-374-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site44a divalent metal cation (UniProtKB | ChEBI)
Binding site58-604-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site63-674-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Site135Transition state stabilizer
Binding site1444-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Molecular Functionmetal ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • EC number
  • Short names
    MECDP-synthase
    ; MECPP-synthase
    ; MECPS

Gene names

    • Name
      ispF
    • Ordered locus names
      Bphyt_1876

Organism names

Accessions

  • Primary accession
    B2T3X3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000942461-1592-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the IspF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    16,743
  • Last updated
    2008-07-01 v1
  • Checksum
    9F42120477775564
MDFRIGQGYDVHALVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDAIFGAAAMGDIGRHFSDTDAKFAGADSRVLLRECFARVKAAGFSIANVDSSVVAQAPKLAPHIEGMRANIAADLGLPVERVNVKAKTNEKLGYLGRGEGIEAQAAVLLIKN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001052
EMBL· GenBank· DDBJ
ACD16284.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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