B2SX27 · B2SX27_PARPJ
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids537 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia
Accessions
- Primary accessionB2SX27
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-63 | Helical | ||||
Sequence: LYLIFSFTMFLSGGVMALMIRA | ||||||
Transmembrane | 83-104 | Helical | ||||
Sequence: TMHGLIMVFGAIMPAFVGFANW | ||||||
Transmembrane | 125-154 | Helical | ||||
Sequence: FWLLPVAAVLLVGSFFSPGGATAAGWTLYA | ||||||
Transmembrane | 166-192 | Helical | ||||
Sequence: FAIFAIHLMGASSIMGGINIVVTILNM | ||||||
Transmembrane | 204-232 | Helical | ||||
Sequence: MFVWTWLITAYLLIAVMPVLAGAITMVLF | ||||||
Transmembrane | 264-282 | Helical | ||||
Sequence: VYIMILPAFGIVSQVIPAF | ||||||
Transmembrane | 294-313 | Helical | ||||
Sequence: VYATSSIAILSFMVWAHHMF | ||||||
Transmembrane | 325-345 | Helical | ||||
Sequence: FMYATMLIAVPTGVKVFNWVA | ||||||
Transmembrane | 357-379 | Helical | ||||
Sequence: PMLFAVGFLLVFTFGGLSGLMLA | ||||||
Transmembrane | 391-416 | Helical | ||||
Sequence: YFVVAHFHYVLVAGSLFALFSGWYYW | ||||||
Transmembrane | 432-453 | Helical | ||||
Sequence: IHFWASMFFFNLAFLPMHFVGL | ||||||
Transmembrane | 473-497 | Helical | ||||
Sequence: VISIGAFGFGLAQVYFLFAVALPAY |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-537 | Cytochrome oxidase subunit I profile | ||||
Sequence: HETPHGWRRWLFATNHKDIGTLYLIFSFTMFLSGGVMALMIRAELFEPGLQIMRPEFFNQLTTMHGLIMVFGAIMPAFVGFANWMVPLQIGASDMAFARMNNFSFWLLPVAAVLLVGSFFSPGGATAAGWTLYAPLSTQMGPGMDFAIFAIHLMGASSIMGGINIVVTILNMRAPGLTLMKMPMFVWTWLITAYLLIAVMPVLAGAITMVLFDRHFGTSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQVIPAFSRKPLFGYSSMVYATSSIAILSFMVWAHHMFATGMPVTGQLFFMYATMLIAVPTGVKVFNWVATMWRGSLSFETPMLFAVGFLLVFTFGGLSGLMLAMAPLDIQYHGTYFVVAHFHYVLVAGSLFALFSGWYYWAPKWTGWMYNETRGKIHFWASMFFFNLAFLPMHFVGLAGMPRRYADYPAQFTDWNQVISIGAFGFGLAQVYFLFAVALPAYRGGGELEKAGDKPWDGATGLEWTVPSPAPFHTFENPPTVE |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length537
- Mass (Da)59,677
- Last updated2008-07-01 v1
- Checksum7D899A81FBF2BE8D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001052 EMBL· GenBank· DDBJ | ACD14970.1 EMBL· GenBank· DDBJ | Genomic DNA |