B2RXY7 · B2RXY7_MOUSE
- ProteinCarbonyl reductase (NADPH)
- GeneCbr1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
- H+ + menadione + NADPH = menadiol + NADP+
- NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPHThis reaction proceeds in the forward direction.
- NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPHThis reaction proceeds in the forward direction.
- corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+This reaction proceeds in the forward direction.
- cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+This reaction proceeds in the forward direction.
- daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbonyl reductase (NADPH) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbonyl reductase (NADPH)
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB2RXY7
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 258-277 | Disordered | ||||
Sequence: PPDAEGPHGQFVQDKKVEPW |
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,641
- Last updated2008-07-01 v1
- Checksum6053423B6D5F82B7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC158026 EMBL· GenBank· DDBJ | AAI58027.1 EMBL· GenBank· DDBJ | mRNA | ||
BC158029 EMBL· GenBank· DDBJ | AAI58030.1 EMBL· GenBank· DDBJ | mRNA |