B2RXY7 · B2RXY7_MOUSE

  • Protein
    Carbonyl reductase (NADPH)
  • Gene
    Cbr1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

  • H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
  • H+ + menadione + NADPH = menadiol + NADP+
  • NADP+ + prostaglandin D2 = 15-oxoprostaglandin D2 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E1 = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin E2
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + H+ + NADPH
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + H+ + NADPH
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbonyl reductase (NADPH) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase (NADPH)
  • EC number

Gene names

    • Name
      Cbr1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B2RXY7

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region258-277Disordered

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,641
  • Last updated
    2008-07-01 v1
  • Checksum
    6053423B6D5F82B7
MSSSRPVALVTGANKGIGFAITRDLCRKFSGDVVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRSETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEPW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC158026
EMBL· GenBank· DDBJ
AAI58027.1
EMBL· GenBank· DDBJ
mRNA
BC158029
EMBL· GenBank· DDBJ
AAI58030.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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