B2RSC8 · B2RSC8_MOUSE
- ProteinE3 ubiquitin-protein ligase
- GeneNedd4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids887 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 854 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | protein ubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB2RSC8
Organism-specific databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 58-183 | C2 | ||||
Sequence: EEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRVLPQRHRILFEVFDENRLTRDDFLGQVDVPLYPLPTENPRMERPY | ||||||
Region | 236-257 | Disordered | ||||
Sequence: PDAATHLPHPPEPSPLPPGWEE | ||||||
Domain | 249-282 | WW | ||||
Sequence: SPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSP | ||||||
Compositional bias | 271-285 | Basic and acidic residues | ||||
Sequence: ESRRTQWKRPSPDDD | ||||||
Region | 271-290 | Disordered | ||||
Sequence: ESRRTQWKRPSPDDDLTDED | ||||||
Region | 302-322 | Disordered | ||||
Sequence: FTTRRQISEDVDGPDNRESPE | ||||||
Compositional bias | 306-322 | Basic and acidic residues | ||||
Sequence: RQISEDVDGPDNRESPE | ||||||
Domain | 405-438 | WW | ||||
Sequence: SGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTM | ||||||
Domain | 460-493 | WW | ||||
Sequence: GPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRL | ||||||
Domain | 552-886 | HECT | ||||
Sequence: RADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGV |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length887
- Mass (Da)102,706
- Last updated2008-07-01 v1
- ChecksumAE7DD3ED63986C50
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 271-285 | Basic and acidic residues | ||||
Sequence: ESRRTQWKRPSPDDD | ||||||
Compositional bias | 306-322 | Basic and acidic residues | ||||
Sequence: RQISEDVDGPDNRESPE |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC138813 EMBL· GenBank· DDBJ | AAI38814.1 EMBL· GenBank· DDBJ | mRNA |