The TgPLN(R9C) mouse strain is in the best case a functionally ambiguous phenocopy of the human PLN(R9C) heterozygote because a similar constellation of genetically programmed events can not occur in a patient
Taken together these results highlight both the importance of using alphaMyHC-Cre mice as controls in conditional knockout studies as well as the need for a less cardiotoxic Cre driver for the field.
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