B2RPX8 · B2RPX8_MOUSE
- ProteinAmmonium transporter Rh type C
- GeneRhcg
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids498 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4+ ion with acidic residues of the pore entry followed by dissociation of NH4+ into NH3 and H+. As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4+. May act as a CO2 channel providing for renal acid secretion.
Catalytic activity
- CO2(out) = CO2(in)This reaction proceeds in the forward direction.
- NH4+(in) = NH4+(out)This reaction proceeds in the forward and the backward directions.
- methylamine(out) = methylamine(in)This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Molecular Function | ammonium channel activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAmmonium transporter Rh type C
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB2RPX8
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | ||||
Sequence: PITCLILQVTMVVLFGVFVRY | ||||||
Transmembrane | 67-87 | Helical | ||||
Sequence: VHAMVFVGFGFLMTFLQRYGF | ||||||
Transmembrane | 94-114 | Helical | ||||
Sequence: FLLAAFGIQWALLMQGWFHYF | ||||||
Transmembrane | 126-145 | Helical | ||||
Sequence: IIQADFCVASSCVAFGAVLG | ||||||
Transmembrane | 152-171 | Helical | ||||
Sequence: LLIMTFFQVTLFTVNEFILL | ||||||
Transmembrane | 183-201 | Helical | ||||
Sequence: MTIHTFGAYFGLTVTWILY | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: SSVYHSDLFAMIGTLFLWIYW | ||||||
Transmembrane | 253-273 | Helical | ||||
Sequence: NTYLSLAASVLTTVTVSSIVH | ||||||
Transmembrane | 280-298 | Helical | ||||
Sequence: MVHIQNATLAGGVGVGTAA | ||||||
Transmembrane | 304-325 | Helical | ||||
Sequence: PYGALIVGFFCGIFSTLGFAYL | ||||||
Transmembrane | 396-417 | Helical | ||||
Sequence: IFGLLLSLAMALVGGIIVGFIL |
Keywords
- Cellular component
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 54-428 | Ammonium transporter AmtB-like | ||||
Sequence: ENEFYYRYPSFQDVHAMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHYFEEGHIVLSVENIIQADFCVASSCVAFGAVLGKVSPMQLLIMTFFQVTLFTVNEFILLNLIEAKDAGGSMTIHTFGAYFGLTVTWILYRKNLDQSKQRQSSVYHSDLFAMIGTLFLWIYWPSFNSASSFHGDAQHRAALNTYLSLAASVLTTVTVSSIVHKKGKLDMVHIQNATLAGGVGVGTAAEMMLTPYGALIVGFFCGIFSTLGFAYLTPFLESRLRIQDTCGIHNLHGIPGIIGGIVGAVTAAYSSPDVYGEPGIVHSFGFGSYKMDWNKRMQGRSQIFGLLLSLAMALVGGIIVGFILKLPFWGQAADE |
Sequence similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length498
- Mass (Da)54,948
- Last updated2008-07-01 v1
- Checksum91DB3E0C847A091C