B2RPX8 · B2RPX8_MOUSE

  • Protein
    Ammonium transporter Rh type C
  • Gene
    Rhcg
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4+ ion with acidic residues of the pore entry followed by dissociation of NH4+ into NH3 and H+. As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4+. May act as a CO2 channel providing for renal acid secretion.

Catalytic activity

  • CO2(out) = CO2(in)
    This reaction proceeds in the forward direction.
  • NH4+(in) = NH4+(out)
    This reaction proceeds in the forward
    and the backward
    directions.
  • methylamine(out) = methylamine(in)
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Molecular Functionammonium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ammonium transporter Rh type C
  • Alternative names
    • Rhesus blood group family type C glycoprotein

Gene names

    • Name
      Rhcg

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B2RPX8

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane67-87Helical
Transmembrane94-114Helical
Transmembrane126-145Helical
Transmembrane152-171Helical
Transmembrane183-201Helical
Transmembrane213-233Helical
Transmembrane253-273Helical
Transmembrane280-298Helical
Transmembrane304-325Helical
Transmembrane396-417Helical

Keywords

  • Cellular component

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-428Ammonium transporter AmtB-like

Sequence similarities

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    498
  • Mass (Da)
    54,948
  • Last updated
    2008-07-01 v1
  • Checksum
    91DB3E0C847A091C
MAWNTNLRGRLPITCLILQVTMVVLFGVFVRYDIQADAHWWLEKKRKNISSDVENEFYYRYPSFQDVHAMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHYFEEGHIVLSVENIIQADFCVASSCVAFGAVLGKVSPMQLLIMTFFQVTLFTVNEFILLNLIEAKDAGGSMTIHTFGAYFGLTVTWILYRKNLDQSKQRQSSVYHSDLFAMIGTLFLWIYWPSFNSASSFHGDAQHRAALNTYLSLAASVLTTVTVSSIVHKKGKLDMVHIQNATLAGGVGVGTAAEMMLTPYGALIVGFFCGIFSTLGFAYLTPFLESRLRIQDTCGIHNLHGIPGIIGGIVGAVTAAYSSPDVYGEPGIVHSFGFGSYKMDWNKRMQGRSQIFGLLLSLAMALVGGIIVGFILKLPFWGQAADENCFEDSIYWEVHEEVNTVYIPEDLAHKHSTSLVPAMPLVLPTTSASIVPPVPPTPPVSLATSAPSAALVH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC137652
EMBL· GenBank· DDBJ
AAI37653.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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