The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J.L., Heuchel R., Itoh S., Kawabata M., Heldin N.-E.[...], ten Dijke P.View abstractCategoriesSequences, InteractionSourceMGI: 1100518PubMedEurope PMCNature 389:631-635 (1997)Cited in2Mapped to6
Smad6 inhibits signalling by the TGF-beta superfamily.Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K.View abstractCategoriesInteractionSourceMGI: 1100518PubMedEurope PMCNature 389:622-626 (1997)Cited in1Mapped to6
Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart.Humeres C., Shinde A.V., Tuleta I., Hernandez S.C., Hanna A., Huang S., Venugopal H., Aguilan J.T., Conway S.J.[...], Frangogiannis N.G.View abstractAnnotationFibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart.SourceGeneRif: 17131PubMedEurope PMCCirc Res 135:453-469 (2024)Mapped to2
UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis.Li W., Bai P., Li W.View abstractAnnotationUHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis.SourceGeneRif: 17131PubMedEurope PMCMol Immunol 170:119-130 (2024)Mapped to16
Linc-smad7 is involved in the regulation of lipid synthesis in mouse mammary epithelial cells.Fang X., Chen J., Meng F., Chen F., Chen X., Wang Y., Fang X., Zhang C., Song C.View abstractAnnotationLinc-smad7 is involved in the regulation of lipid synthesis in mouse mammary epithelial cells.SourceGeneRif: 17131PubMedEurope PMCInt J Biol Macromol 262:129875-129875 (2024)Mapped to2
Nicotinamide phosphoribose transferase facilitates macrophage-mediated pulmonary fibrosis through the Sirt1-Smad7 pathway in mice.Zhan T., Chen Y., Dong L., Wei T., Lu D., Wang Q., Wu Z., Xu J., Ge M.View abstractAnnotationNicotinamide phosphoribose transferase facilitates macrophage-mediated pulmonary fibrosis through the Sirt1-Smad7 pathway in mice.SourceGeneRif: 17131PubMedEurope PMCEur J Pharmacol 967:176355-176355 (2024)Mapped to4
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.Liang S., Zheng R., Zuo B., Li J., Wang Y., Han Y., Dong H., Zhao X., Zhang Y.[...], Yan B.View abstractAnnotationSMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.SourceGeneRif: 17131PubMedEurope PMCCell Mol Immunol 21:213-226 (2024)Mapped to4
Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI.Xu X., Guo Y., Luo X., Shen Z., Sun Z., Shen B., Zhou C., Wang J., Lu J.[...], Lu L.View abstractAnnotationHydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI.CategoriesFunctionSourceGeneRif: 17131PubMedEurope PMCLiver Int 43:2523-2537 (2023)Mapped to7
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.Liu C., Wu J., Li M., Gao R., Zhang X., Ye-Lehmann S., Song J., Zhu T., Chen C.View abstractAnnotationSmad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.CategoriesSubcellular LocationSourceGeneRif: 17131PubMedEurope PMCJ Neuroinflammation 20:175-175 (2023)Mapped to2
IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.Ke Y., Li B.Z., Nguyen K., Wang D., Wang S., Young C.D., Wang X.J.View abstractAnnotationIL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.SourceGeneRif: 17131PubMedEurope PMCJ Invest Dermatol 143:2243-2254.e10 (2023)Mapped to2
Topologically associating domain boundaries are required for normal genome function.Rajderkar S., Barozzi I., Zhu Y., Hu R., Zhang Y., Li B., Alcaina Caro A., Fukuda-Yuzawa Y., Kelman G.[...], Pennacchio L.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1100518PubMedEurope PMCCommun Biol 6:435-435 (2023)Mapped to59
Astrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation.He X., Huang Y., Liu Y., Zhang X., Wang Q., Liu Y., Ma X., Long X., Ruan Y.[...], Zhang H.View abstractAnnotationAstrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation.CategoriesFunction, ExpressionSourceGeneRif: 17131PubMedEurope PMCMol Ther 31:1313-1331 (2023)Mapped to2
Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis.Schuler C., Foti F., Perren L., Mamie C., Weder B., Stokmaier M., de Valliere C., Heuchel R., Ruiz P.A.[...], Hausmann M.View abstractAnnotationDeletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 17131PubMedEurope PMCInflamm Bowel Dis 29:647-660 (2023)Mapped to2
MicroRNA-181b promotes schistosomiasis-induced hepatic fibrosis by targeting Smad7.Wang S., Zhang J., Chen H., Zhan X., Nie H., Wang C., Zhang Y., Zheng B., Gong Q.View abstractAnnotationMicroRNA-181b promotes schistosomiasis-induced hepatic fibrosis by targeting Smad7.CategoriesFunction, ExpressionSourceGeneRif: 17131PubMedEurope PMCMol Biochem Parasitol 252:111523-111523 (2022)Mapped to2
LncRNA-Smad7 mediates cross-talk between Nodal/TGF-beta and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells.Kong X., Yan K., Deng P., Fu H., Sun H., Huang W., Jiang S., Dai J., Zhang Q.C.[...], Xi Q.View abstractAnnotationLncRNA-Smad7 mediates cross-talk between Nodal/TGF-beta and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells.CategoriesFunctionSourceGeneRif: 17131, MGI: 1100518PubMedEurope PMCNucleic Acids Res 50:10526-10543 (2022)Mapped to4
Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7.Lee H., Yu D.M., Bahn M.S., Kwon Y.J., Um M.J., Yoon S.Y., Kim K.T., Lee M.W., Jo S.J.[...], Ko Y.G.View abstractAnnotationHepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7.CategoriesInteractionSourceGeneRif: 17131PubMedEurope PMCExp Mol Med 54:1277-1289 (2022)Mapped to11
The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction.Li J., Li R., Tuleta I., Hernandez S.C., Humeres C., Hanna A., Chen B., Frangogiannis N.G.View abstractAnnotationThe role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction.CategoriesFunction, ExpressionSourceGeneRif: 17131, MGI: 1100518PubMedEurope PMCFASEB J 36:e22400-e22400 (2022)Mapped to6
Exosomal microRNA-16-5p from macrophage exacerbates atherosclerosis via modulating mothers against decapentaplegic homolog 7.Chen F., Li J., She J., Chen T., Yuan Z.View abstractAnnotationExosomal microRNA-16-5p from macrophage exacerbates atherosclerosis via modulating mothers against decapentaplegic homolog 7.CategoriesFunction, ExpressionSourceGeneRif: 17131PubMedEurope PMCMicrovasc Res 142:104368-104368 (2022)Mapped to2
Molecular mechanism of the TGF‑beta/Smad7 signaling pathway in ulcerative colitis.Bai B., Li H., Han L., Mei Y., Hu C., Mei Q., Xu J., Liu X.View abstractAnnotationMolecular mechanism of the TGFbeta/Smad7 signaling pathway in ulcerative colitis.CategoriesFunction, ExpressionSourceGeneRif: 17131PubMedEurope PMCMol Med Rep 25:116-116 (2022)Mapped to4
Genome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells.Meng G., Lauria A., Maldotti M., Anselmi F., Polignano I.L., Rapelli S., Donna D., Oliviero S.View abstractAnnotationGenome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells.CategoriesFunctionSourceGeneRif: 17131PubMedEurope PMCInt J Mol Sci 22:13598-13598 (2021)Mapped to2
Smad7 effects on TGF-beta and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure.Humeres C., Shinde A.V., Hanna A., Alex L., Hernandez S.C., Li R., Chen B., Conway S.J., Frangogiannis N.G.View abstractAnnotationSmad7 effects on TGF-beta and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure.CategoriesFunctionSourceGeneRif: 17131PubMedEurope PMCJ Clin Invest 132:e146926-e146926 (2022)Mapped to9
SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning.Gamart J., Barozzi I., Laurent F., Reinhardt R., Martins L.R., Oberholzer T., Visel A., Zeller R., Zuniga A.View abstractCategoriesFunction, ExpressionSourceMGI: 1100518PubMedEurope PMCDevelopment 148:dev200182-dev200182 (2021)Mapped to99+
Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl<sub>4</sub> Exposure in Mice.Unrau L., Endig J., Goltz D., Sprezyna P., Ulrich H., Hagenstein J., Geers B., Kaftan K., Heukamp L.C.[...], Diehl L.View abstractAnnotationSmad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury Inflammation or Fibrosis after Chronic CCl4 Exposure in Mice.CategoriesFunction, ExpressionSourceGeneRif: 17131, MGI: 1100518PubMedEurope PMCInt J Mol Sci 22:11575-11575 (2021)Mapped to6
Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme.Dennison B.J.C., Larson E.D., Fu R., Mo J., Fantauzzo K.A.View abstractCategoriesFunctionSourceMGI: 1100518PubMedEurope PMCDevelopment 148:dev199448-dev199448 (2021)Mapped to99+