B2RIE8 · MRAY_PORG3
- ProteinPhospho-N-acetylmuramoyl-pentapeptide-transferase
- GenemraY
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids419 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Catalytic activity
- UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP
Cofactor
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | phospho-N-acetylmuramoyl-pentapeptide-transferase activity | |
Molecular Function | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospho-N-acetylmuramoyl-pentapeptide-transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Bacteroidia > Bacteroidales > Porphyromonadaceae > Porphyromonas
Accessions
- Primary accessionB2RIE8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-42 | Helical | ||||
Sequence: YVSFRSAVAIILALLLATVIG | ||||||
Transmembrane | 72-92 | Helical | ||||
Sequence: TPTMGGLIIIISILIPTLLLA | ||||||
Transmembrane | 99-119 | Helical | ||||
Sequence: ILLMIVTTLLLGSLGFLDDYI | ||||||
Transmembrane | 135-155 | Helical | ||||
Sequence: IIGQVGLGFIIGIVLYMNPAV | ||||||
Transmembrane | 208-228 | Helical | ||||
Sequence: VLFGWILFVCVAVVVVTFISN | ||||||
Transmembrane | 238-258 | Helical | ||||
Sequence: GLATGSSAIIGVVLAIFAYVS | ||||||
Transmembrane | 278-298 | Helical | ||||
Sequence: LTIFAFAFVGATIGFLWYNAY | ||||||
Transmembrane | 303-323 | Helical | ||||
Sequence: FMGDTGSLTLGGIIAVFALII | ||||||
Transmembrane | 328-348 | Helical | ||||
Sequence: LLPILCFVFIIEGLSVMIQVF | ||||||
Transmembrane | 396-416 | Helical | ||||
Sequence: KITVRFWLVGIIMAAITIATL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000090656 | 1-419 | Phospho-N-acetylmuramoyl-pentapeptide-transferase | |||
Sequence: MLYYLFDYLEKLQLPGARLFHYVSFRSAVAIILALLLATVIGNRIIERLRKAQIGETIRDLGLEGQLSKKGTPTMGGLIIIISILIPTLLLARLDNVYILLMIVTTLLLGSLGFLDDYIKVFRKKKEGLHGRYKIIGQVGLGFIIGIVLYMNPAVVIKENSEVLRDGQVERVHFNKQEVKSTKTTIPFVKNNNFDYADILPFEGKTKVLFGWILFVCVAVVVVTFISNCANLTDGLDGLATGSSAIIGVVLAIFAYVSSHIEMASYLNIMFIPGAEELTIFAFAFVGATIGFLWYNAYPAQVFMGDTGSLTLGGIIAVFALIIRKEMLLPILCFVFIIEGLSVMIQVFYFKLTKRRTGEGRRIFKMTPLHHHFQKPGNAGIDAWLQKPMQAIPESKITVRFWLVGIIMAAITIATLKMR |
Structure
Sequence
- Sequence statusComplete
- Length419
- Mass (Da)46,695
- Last updated2008-07-01 v1
- Checksum5D91C69AF45441DA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP009380 EMBL· GenBank· DDBJ | BAG33143.1 EMBL· GenBank· DDBJ | Genomic DNA |