B2RC52 · B2RC52_HUMAN

  • Protein
    ATP-sensitive inward rectifier potassium channel 11
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Features

Showing features for site.

139050100150200250300350
TypeIDPosition(s)Description
Site160Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentaxolemma
Cellular Componentcell body fiber
Cellular Componentendosome
Cellular Componentglutamatergic synapse
Cellular Componentintercalated disc
Cellular Componentinward rectifying potassium channel
Cellular Componentneuronal cell body
Cellular Componentnuclear envelope
Cellular Componentpresynaptic membrane
Cellular ComponentT-tubule
Molecular Functionankyrin binding
Molecular FunctionATP binding
Molecular FunctionATP-activated inward rectifier potassium channel activity
Molecular FunctionATPase-coupled monoatomic cation transmembrane transporter activity
Molecular Functionheat shock protein binding
Molecular Functiontransmembrane transporter binding
Biological Processaction potential
Biological Processapoptotic process
Biological ProcessCAMKK-AMPK signaling cascade
Biological Processcellular response to glucose stimulus
Biological Processcellular response to nicotine
Biological Processcellular response to tumor necrosis factor
Biological Processdetermination of adult lifespan
Biological Processnegative regulation of insulin secretion
Biological Processpositive regulation of protein localization to plasma membrane
Biological Processpotassium ion import across plasma membrane
Biological Processregulation of monoatomic ion transmembrane transport
Biological Processresponse to ATP
Biological Processresponse to estradiol
Biological Processresponse to hypoxia
Biological Processresponse to ischemia
Biological Processresponse to resveratrol
Biological Processresponse to testosterone
Biological Processresponse to xenobiotic stimulus
Biological Processventricular cardiac muscle tissue development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP-sensitive inward rectifier potassium channel 11
  • Alternative names
    • Inward rectifier K(+) channel Kir6.2
    • Potassium channel, inwardly rectifying subfamily J member 11

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B2RC52

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane72-93Helical
Transmembrane144-168Helical

Keywords

  • Cellular component

Disease & Variants

Organism-specific databases

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-173Potassium channel inwardly rectifying transmembrane
Domain181-352Inward rectifier potassium channel C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    43,526
  • Last updated
    2008-07-01 v1
  • Checksum
    00F4E7D94432F282
MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK314943
EMBL· GenBank· DDBJ
BAG37449.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp