The results of this study indicate that ACSL6 contributes to the local accumulation of docosahexaenoic acid and docosapentaenoic acid containing phospholipids in spermatids to support normal spermatogenesis
The alternative fatty acid Gate-domain motifs are essential determinants for the activity of the human ACSL6 isoforms which appear to act as homodimeric enzyme as well as in complex with other spliced forms.
Observational study of gene-disease association. (HuGE Navigator); ACSL6 is highly associated with schizophrenia and several haplotypes in this haploblock have about twofold to 10-fold increase in the affected subjects in Han Chinese.
Associated with REPRODUCTION: Ovarian Failure, Premature., Observational study and genome-wide association study of gene-disease association. (HuGE Navigator); The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes.
Associated with PSYCH: schizophrenia., Observational study of gene-disease association. (HuGE Navigator); haplotypes underlying the SPEC2/PDZ-GEF2/ACSL6 region are associated with schizophrenia
Three ACSL6 spliced variants of a mutually exclusive exon pair are reported they encode a slightly different short motif which contains a conserved structural domain the fatty acid Gate domain.
Not Associated with PSYCH: schizoaffective disorder schizophrenia., Analyses did not yield convincing evidence for associations of schizophrenia with ACSL6; Observational study of gene-disease association and genetic testing. (HuGE Navigator)
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