Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients.
It is an intracellular central metabolic sensor as well as a regulator has been demonstrated to play significant roles in the contracting skeletal muscles suggesting that AMPK should be one of the key molecules mediating metabolic effects during physical exercise.
Mechanistically AMP-activated protein kinase (AMPK)-mediated phosphorylation of BECN1 at Ser90/93/96 is required for BECN1-SLC7A11 complex formation and lipid peroxidation.
A double-negative feedback loop between Akt and AMPK controls the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during breast cancer metastasis.
PGC-1alpha protein was higher after HIHVT than after SIT (p < 0.05). Moreover the AMPKpTHR172/AMPK ratio increased at post after SIT (p < 0.05) whereas this effect was delayed after HIHVT as it increased after 3 h
TNF-alpha treatment of colonic rho(0) cells augmented IL-8 expression by 9-fold (P < 0.01) via NF-kappaB compared to TNF-alpha-treated control. Moreover reduced mitochondrial function facilitated TNF-alpha-mediated NF-kappaB luciferase promoter activity as a result of lowered inhibitory IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor alpha) leading to elevated NF-kappaB. ...
Data suggest that the AMPK-TBC1D4 signaling axis is likely mediating the improved muscle insulin sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK in skeletal muscle.
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