study uncover that the RING domain of XIAP supports c-Myc protein stability providing insight into the molecular mechanism and role of c-Myc overexpression in cancer progression.
The cellular apoptosis susceptibility/importin-alpha1 transport cycle is linked to XIAP and is required to maintain tumor cell survival in hepatocellular carcinoma.
Using gene reporter assays we show that promoter variations in 11 intrinsic apoptosis genes including ADPRT APAF1 BCL2 BAD BID MCL1 BIRC4 BCL2L1 ENDOG YWHAB and YWHAQ influence promoter activity in an allele-specific manner.
Resveratrol induces p53-independent X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.
p53 activation enhances XIAP inhibition-induced cell death by promoting mitochondrial release of second mitochondria-derived activator of caspases (SMAC) and by inducing the expression of caspase-6.
data suggest that the sensitization to radiation results from NBS1-siRNA-mediated suppression of DNA repair and/ or X-ray-induced cell survival signaling pathways through NFKB and XIAP.
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