X-linked inhibitor of apoptosis protein (XIAP) predicts disease-free survival in BRAFV600E mutant papillary thyroid carcinoma in middle eastern patients.
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells; XIAP-deficiency results in increased TNFR1- and TNFR2- driven pathology in the intestinal tract. This drives a severe disease phenotype that is associated with damaged Paneth cells and microbial dysbiosis.
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