B2R7U4 · B2R7U4_HUMAN
- ProteinHeme oxygenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids288 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
Catalytic activity
- heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]This reaction proceeds in the forward direction.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | heme binding | |
Molecular Function | heme oxygenase (decyclizing) activity | |
Molecular Function | metal ion binding | |
Biological Process | heme catabolic process | |
Biological Process | heme oxidation | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHeme oxygenase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB2R7U4
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 268-287 | Helical | ||||
Sequence: LRWVLTLSFLVATVAVGLYA |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 223-263 | Disordered | ||||
Sequence: HDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRS | ||||||
Compositional bias | 227-248 | Polar residues | ||||
Sequence: DQSPSRAPGLRQRASNKVQDSA |
Sequence similarities
Belongs to the heme oxygenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length288
- Mass (Da)32,803
- Last updated2008-07-01 v1
- ChecksumAB478277787D4124
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 227-248 | Polar residues | ||||
Sequence: DQSPSRAPGLRQRASNKVQDSA |