B2R7U4 · B2R7U4_HUMAN

Function

function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Catalytic activity

Features

Showing features for binding site.

128820406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site18heme b (UniProtKB | ChEBI)
Binding site25Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue
Binding site134heme b (UniProtKB | ChEBI)
Binding site183heme b (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionheme binding
Molecular Functionheme oxygenase (decyclizing) activity
Molecular Functionmetal ion binding
Biological Processheme catabolic process
Biological Processheme oxidation
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme oxygenase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B2R7U4

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type IV membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane268-287Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region223-263Disordered
Compositional bias227-248Polar residues

Sequence similarities

Belongs to the heme oxygenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    288
  • Mass (Da)
    32,803
  • Last updated
    2008-07-01 v1
  • Checksum
    AB478277787D4124
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPPLRWVLTLSFLVATVAVGLYAM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias227-248Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK313120
EMBL· GenBank· DDBJ
BAG35941.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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