B2R6Q4 · B2R6Q4_HUMAN

  • Protein
    Tyrosine-protein kinase
  • Gene
    CSK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

145050100150200250300350400450
TypeIDPosition(s)Description
Binding site222ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell-cell junction
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionnon-membrane spanning protein tyrosine kinase activity
Molecular Functionproline-rich region binding
Molecular Functionprotein phosphatase binding
Molecular Functionprotein tyrosine kinase binding
Biological Processadherens junction organization
Biological Processcellular response to peptide hormone stimulus
Biological Processnegative regulation of bone resorption
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of low-density lipoprotein particle clearance
Biological Processnegative regulation of phagocytosis
Biological Processoligodendrocyte differentiation
Biological Processprotein phosphorylation
Biological Processregulation of Fc receptor mediated stimulatory signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase
  • EC number

Gene names

    • Name
      CSK
    • ORF names
      hCG_40804

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B2R6Q4

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

Keywords

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-70SH3
Domain82-171SH2
Domain195-449Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    50,704
  • Last updated
    2008-07-01 v1
  • Checksum
    431023A88C54E00C
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK312669
EMBL· GenBank· DDBJ
BAG35551.1
EMBL· GenBank· DDBJ
mRNA
AK127672
EMBL· GenBank· DDBJ
BAG54548.1
EMBL· GenBank· DDBJ
mRNA
CH471136
EMBL· GenBank· DDBJ
EAW99311.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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