B2R6Q4 · B2R6Q4_HUMAN
- ProteinTyrosine-protein kinase
- GeneCSK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids450 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell-cell junction | |
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | non-membrane spanning protein tyrosine kinase activity | |
Molecular Function | proline-rich region binding | |
Molecular Function | protein phosphatase binding | |
Molecular Function | protein tyrosine kinase binding | |
Biological Process | adherens junction organization | |
Biological Process | cellular response to peptide hormone stimulus | |
Biological Process | negative regulation of bone resorption | |
Biological Process | negative regulation of cell population proliferation | |
Biological Process | negative regulation of ERK1 and ERK2 cascade | |
Biological Process | negative regulation of interleukin-6 production | |
Biological Process | negative regulation of low-density lipoprotein particle clearance | |
Biological Process | negative regulation of phagocytosis | |
Biological Process | oligodendrocyte differentiation | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of Fc receptor mediated stimulatory signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB2R6Q4
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-70 | SH3 | ||||
Sequence: PSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG | ||||||
Domain | 82-171 | SH2 | ||||
Sequence: WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPK | ||||||
Domain | 195-449 | Protein kinase | ||||
Sequence: LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELH |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length450
- Mass (Da)50,704
- Last updated2008-07-01 v1
- Checksum431023A88C54E00C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK312669 EMBL· GenBank· DDBJ | BAG35551.1 EMBL· GenBank· DDBJ | mRNA | ||
AK127672 EMBL· GenBank· DDBJ | BAG54548.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471136 EMBL· GenBank· DDBJ | EAW99311.1 EMBL· GenBank· DDBJ | Genomic DNA |