B2R4S9 · B2R4S9_HUMAN

  • Protein
    Histone H2B
  • Gene
    HIST1H2BE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular space
Cellular Componentnucleoplasm
Cellular Componentnucleosome
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin
Biological Processantibacterial humoral response
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processdefense response to Gram-positive bacterium
Biological Processinnate immune response in mucosa

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H2B

Gene names

    • Name
      HIST1H2BE
    • Synonyms
      HIST1H2BC
      , HIST1H2BF
      , HIST1H2BG
      , HIST1H2BI
    • ORF names
      hCG_1640484
      , hCG_1640985
      , hCG_1641780
      , hCG_1787353
      , hCG_1787365

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B2R4S9

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

PTM databases

Expression

Gene expression databases

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-36Disordered
Domain11-101Histone H2A/H2B/H3
Compositional bias17-35Basic residues

Sequence similarities

Belongs to the histone H2B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    126
  • Mass (Da)
    13,906
  • Last updated
    2008-07-01 v1
  • Checksum
    FAE1479F44BE703D
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias17-35Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK311935
EMBL· GenBank· DDBJ
BAG34876.1
EMBL· GenBank· DDBJ
mRNA
AK312096
EMBL· GenBank· DDBJ
BAG35032.1
EMBL· GenBank· DDBJ
mRNA
CH471087
EMBL· GenBank· DDBJ
EAW55530.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471087
EMBL· GenBank· DDBJ
EAW55537.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471087
EMBL· GenBank· DDBJ
EAW55543.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471087
EMBL· GenBank· DDBJ
EAW55545.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471087
EMBL· GenBank· DDBJ
EAW55554.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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