B2MWM9 · B2MWM9_MOUSE

  • Protein
    Calreticulin
  • Gene
    Calr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Features

Showing features for binding site.

141650100150200250300350400
TypeIDPosition(s)Description
Binding site26Ca2+ (UniProtKB | ChEBI)
Binding site62Ca2+ (UniProtKB | ChEBI)
Binding site64Ca2+ (UniProtKB | ChEBI)
Binding site109an alpha-D-glucoside (UniProtKB | ChEBI)
Binding site111an alpha-D-glucoside (UniProtKB | ChEBI)
Binding site128an alpha-D-glucoside (UniProtKB | ChEBI)
Binding site135an alpha-D-glucoside (UniProtKB | ChEBI)
Binding site317an alpha-D-glucoside (UniProtKB | ChEBI)
Binding site328Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentcell surface
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentcortical granule
Cellular Componentcytosol
Cellular Componentextracellular space
Cellular Componentglutamatergic synapse
Cellular ComponentMHC class I peptide loading complex
Cellular Componentnuclear envelope
Cellular Componentperinuclear region of cytoplasm
Cellular Componentpostsynapse
Cellular Componentribosome
Cellular Componentsarcoplasmic reticulum lumen
Cellular Componentsmooth endoplasmic reticulum
Molecular Functioncalcium ion binding
Molecular Functioncomplement component C1q complex binding
Molecular Functionhormone binding
Molecular Functionintegrin binding
Molecular Functioniron ion binding
Molecular Functionmolecular sequestering activity
Molecular FunctionmRNA binding
Molecular Functionnuclear androgen receptor binding
Molecular Functionnuclear export signal receptor activity
Molecular Functionpeptide binding
Molecular Functionubiquitin protein ligase binding
Molecular Functionunfolded protein binding
Biological Processcardiac muscle cell differentiation
Biological Processcellular response to electrical stimulus
Biological Processcellular response to lithium ion
Biological Processcellular response to virus
Biological Processcellular senescence
Biological Processnegative regulation of intracellular steroid hormone receptor signaling pathway
Biological Processnegative regulation of neuron differentiation
Biological Processnegative regulation of retinoic acid receptor signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of translation
Biological Processnegative regulation of trophoblast cell migration
Biological Processpeptide antigen assembly with MHC class I protein complex
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of dendritic cell chemotaxis
Biological Processpositive regulation of endothelial cell migration
Biological Processpositive regulation of substrate adhesion-dependent cell spreading
Biological Processprotein export from nucleus
Biological Processprotein folding
Biological Processprotein localization to nucleus
Biological Processresponse to biphenyl
Biological Processresponse to estradiol
Biological Processresponse to glycoside
Biological Processresponse to peptide
Biological Processresponse to testosterone
Biological Processresponse to xenobiotic stimulus
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calreticulin

Gene names

    • Name
      Calr

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KM
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B2MWM9

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_501420520918-416Calreticulin
Disulfide bond105↔137

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region193-278Disordered
Compositional bias199-254Basic and acidic residues
Region350-416Disordered
Compositional bias352-381Basic and acidic residues
Compositional bias382-416Acidic residues

Sequence similarities

Belongs to the calreticulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    47,995
  • Last updated
    2008-06-10 v1
  • Checksum
    24C03B00913408D8
MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDLEKDKGLQTSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDDRDEDEDEEDEKEEDEEESPGQAKDEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias199-254Basic and acidic residues
Compositional bias352-381Basic and acidic residues
Compositional bias382-416Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU639407
EMBL· GenBank· DDBJ
ACC77467.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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