B2KKU5 · B2KKU5_MOUSE
- ProteinTafazzin family protein
- GeneTafazzin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids150 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
Catalytic activity
- 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward and the backward directions.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineThis reaction proceeds in the forward and the backward directions.
- a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphateThis reaction proceeds in the forward and the backward directions.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)This reaction proceeds in the forward and the backward directions.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward and the backward directions.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | acyltransferase activity | |
Biological Process | phospholipid metabolic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTafazzin family protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB2KKU5
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Mitochondrion outer membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Associates with multiple protein complexes.
Structure
Sequence
- Sequence statusFragment
- Length150
- Mass (Da)17,434
- Last updated2008-06-10 v1
- MD5 ChecksumEA80D431A046D69FF9833473CAA84957
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 150 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF524069 EMBL· GenBank· DDBJ | ABP82771.1 EMBL· GenBank· DDBJ | mRNA |