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B2KKU5 · B2KKU5_MOUSE

  • Protein
    Tafazzin family protein
  • Gene
    Tafazzin
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.

Catalytic activity

  • 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward
    and the backward
    directions.
  • a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward
    and the backward
    directions.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial outer membrane
Molecular Functionacyltransferase activity
Biological Processphospholipid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tafazzin family protein

Gene names

    • Name
      Tafazzin
    • Synonyms
      TAZ
      , Taz

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B2KKU5

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein
Mitochondrion outer membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Associates with multiple protein complexes.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-150Phospholipid/glycerol acyltransferase

Sequence similarities

Belongs to the taffazin family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    150
  • Mass (Da)
    17,434
  • Last updated
    2008-06-10 v1
  • MD5 Checksum
    EA80D431A046D69FF9833473CAA84957
YMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGVDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVEN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue150

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF524069
EMBL· GenBank· DDBJ
ABP82771.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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