B2JEQ7 · PANC_PARP8
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 26-33 | ATP (UniProtKB | ChEBI) | |||
Active site | 33 | Proton donor | |||
Binding site | 57 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 57 | beta-alanine (UniProtKB | ChEBI) | |||
Binding site | 144-147 | ATP (UniProtKB | ChEBI) | |||
Binding site | 150 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 173 | ATP (UniProtKB | ChEBI) | |||
Binding site | 181-184 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia
Accessions
- Primary accessionB2JEQ7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000097041 | 1-277 | Pantothenate synthetase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)31,049
- Last updated2008-06-10 v1
- Checksum3AC40A160AFE4B71
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001043 EMBL· GenBank· DDBJ | ACC71372.1 EMBL· GenBank· DDBJ | Genomic DNA |