B2JEQ7 · PANC_PARP8

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site26-33ATP (UniProtKB | ChEBI)
Active site33Proton donor
Binding site57(R)-pantoate (UniProtKB | ChEBI)
Binding site57beta-alanine (UniProtKB | ChEBI)
Binding site144-147ATP (UniProtKB | ChEBI)
Binding site150(R)-pantoate (UniProtKB | ChEBI)
Binding site173ATP (UniProtKB | ChEBI)
Binding site181-184ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • Ordered locus names
      Bphy_2197

Organism names

Accessions

  • Primary accession
    B2JEQ7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000970411-277Pantothenate synthetase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    31,049
  • Last updated
    2008-06-10 v1
  • Checksum
    3AC40A160AFE4B71
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLEADIEKLQKENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPGFFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQFALPTDIVAAETVRDTDGLALSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAIRKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001043
EMBL· GenBank· DDBJ
ACC71372.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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