B2JE92 · B2JE92_PARP8

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1773100200300400500600700
Type
IDPosition(s)Description
Site51Interaction with DNA
Site87Interaction with DNA
Site89Interaction with DNA
Site130Transition state stabilizer
Active site131O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      parC
    • Ordered locus names
      Bphy_2123

Organism names

Accessions

  • Primary accession
    B2JE92

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

Type
IDPosition(s)Description
Domain20-492DNA topoisomerase type IIA
Coiled coil457-516
Compositional bias740-762Basic and acidic residues
Region740-773Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    773
  • Mass (Da)
    84,548
  • Last updated
    2008-06-10 v1
  • MD5 Checksum
    43285AA8E6675581E5D432106507CE40
MDDNTPDLFTEPAAPEGDVLTLGNYAERAYLDYAVSVVKGRALPDVCDGQKPVQRRILYAMNEMGLGDNAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKLLPARLPFVLLNGASGIAVGLATEIPSHNLREVAAAAVAMIRHPKITHAELMQLVPGPDFPGGGQIISSEAEISQAYETGRGSLKVRARWKIEDLARGQWQLVITELPPNTSGQKVLEEIEEQTNPKIKLGKKSLTPEQLQTKQTLLGLLDAVRDESGKDAPVRLVFEPKSSRIDQTEFVNTLLAHTSLESNATLNLVMVGADGRPRQKGIGEMLHEWIGFRFTTVTRRSQHRLNKVNERIHILEGRMIVFLNIDEVIRIIRESEEPKAALIEAFKLSDRQAEDILEIRLRQLARLEAIKIEKELSELRDEKAKLEELLGSEPAMKRLLIKEIEADAKQYGDDRRTLIQQEKRATFEARVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGDGLYAAFQCRTPDMLIAWGSKGRVYSVAVSQLPGGRGDGVPVTSLIELESGTHLMHYYAASAEQALLLASSNGFGFIAKVGDMVSRVKAGKAFMTIDEGATPLAPMPMLPDATQVACLSGGGRLLVFGLDEMKTLSGGGRGVILMALDPNEVLKQALAISNAGVVLQGVYRNKPMEEELSGKALEPNVGKRARKGRVPDTKLKEVTSLRPVLPG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias740-762Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001043
EMBL· GenBank· DDBJ
ACC71300.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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