B2JE92 · B2JE92_PARP8
- ProteinDNA topoisomerase 4 subunit A
- GeneparC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids773 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 51 | Interaction with DNA | |||
Site | 87 | Interaction with DNA | |||
Site | 89 | Interaction with DNA | |||
Site | 130 | Transition state stabilizer | |||
Active site | 131 | O-(5'-phospho-DNA)-tyrosine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | |
Cellular Component | extrinsic component of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia
Accessions
- Primary accessionB2JE92
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-492 | DNA topoisomerase type IIA | |||
Coiled coil | 457-516 | ||||
Compositional bias | 740-762 | Basic and acidic residues | |||
Region | 740-773 | Disordered | |||
Sequence similarities
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length773
- Mass (Da)84,548
- Last updated2008-06-10 v1
- MD5 Checksum43285AA8E6675581E5D432106507CE40
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 740-762 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001043 EMBL· GenBank· DDBJ | ACC71300.1 EMBL· GenBank· DDBJ | Genomic DNA |