B2HIL7 · MSL7_MYCMM

Function

function

Catalyzes the elongation by iterative transfer of p-hydroxybenzoyl group from FadD22 (pHBA-S-FAdD22) to form p-hydroxyphenylalkanoate (pHPA) intermediates during phenolphthiocerol (PPOL) biosynthesis. PPOL is an important intermediate in the biosynthesis of phenolic glycolipid (mycosid B).

Cofactor

pantetheine 4'-phosphate (UniProtKB | Rhea| CHEBI:47942 )

Note: Binds 1 phosphopantetheine covalently.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site211For beta-ketoacyl synthase activity
Active site346For beta-ketoacyl synthase activity
Active site386For beta-ketoacyl synthase activity
Active site662For acyltransferase activity
Active site967Proton acceptor; for dehydratase activity
Active site1128Proton donor; for dehydratase activity
Binding site1530-1547NADP+ (UniProtKB | ChEBI)
Binding site1719-1734NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentpolyketide synthase complex
Molecular Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Functionfatty acid synthase activity
Molecular Functionoxidoreductase activity
Molecular Functionphosphopantetheine binding
Biological ProcessActinobacterium-type cell wall biogenesis
Biological ProcessDIM/DIP cell wall layer assembly
Biological Processfatty acid biosynthetic process
Biological Processlipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
  • Alternative names
    • Beta-ketoacyl-acyl-carrier-protein synthase I (EC:2.3.1.41) . EC:2.3.1.41 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      pks15/1
    • Synonyms
      msl7
    • Ordered locus names
      MMAR_1762

Organism names

Accessions

  • Primary accession
    B2HIL7

Proteomes

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis211The pHBA starter unit is not loaded onto Pks15/1 and thus the pHPA intermediate is not produced.
Mutagenesis2039The pHBA starter unit is loaded onto Pks15/1, but the pHPA intermediate is not produced.

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00004063611-2104Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
Modified residue2039O-(pantetheine 4'-phosphoryl)serine

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain41-464Ketosynthase family 3 (KS3)
Region571-887Acyltransferase
Region935-1057N-terminal hotdog fold
Region935-1095Dehydratase
Domain935-1207PKS/mFAS DH
Region1069-1207C-terminal hotdog fold
Region1400-1705Enoylreductase
Region1718-1899Beta-ketoacyl reductase (KR)
Domain2004-2079Carrier
Region2081-2104Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,104
  • Mass (Da)
    217,744
  • Last updated
    2008-06-10 v1
  • Checksum
    7A33F823206BDCA5
MTTSGESADQQNDKLFRYLKKVAVELDEARARLREYEQRATEPVAVVGIGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMSLRGSSTGVFTGIFAPSYGGKDVGALQGYGLTGSPVSVASGRVAYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVRGSAINQDGASNGLTAPNGLAQQRVIQAALANCGLTSADVDVVEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPDAGRPRRAGVSSFGISGTNAHVILEEAPAPEAVPDSESNKGEPSLPVVPWVISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAGRSAFEHRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLREVMWGSDAALLDSTEFAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPAEAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGAADDSGNRALSVYSRGDQSEDWLLNAEGMLGVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQGLVGVWRRDSELFAEVVAPSGVAVDKMGMHPVVLDAVLHALGLTAEQNPDSDETKLPFCWRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPVLTVGALVTRAMSAAQLRAAVAAAGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVVVWEPNPAGEDVVGSVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLLAVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMYPGEAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVGAVLARHMLDAYGVRHLVLASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRLKSATGLTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEEKLPESDGEMVSVTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000854
EMBL· GenBank· DDBJ
ACC40211.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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