B2HEM2 · CTPC_MYCMM
- ProteinZinc-exporting P-type ATPase
- GenectpC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids732 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Zn2+ efflux transporter which is involved in detoxification of zinc during infection.
Miscellaneous
Increasing concentrations of Mn2+ does not affect the growth of the wild-type strain, nor that of the deletion mutant, excluding that M.marinum CtpC is a manganese exporter as M.tuberculosis CtpC.
Catalytic activity
- Zn2+(in) + ATP + H2O = Zn2+(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.Zn2+ (in)CHEBI:29105
+ CHEBI:30616 + CHEBI:15377 = Zn2+ (out)CHEBI:29105+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 423 | 4-aspartylphosphate intermediate | |||
Binding site | 423 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 425 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 625 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | copper ion binding | |
Molecular Function | P-type divalent copper transporter activity | |
Biological Process | copper ion homeostasis | |
Biological Process | zinc ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc-exporting P-type ATPase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium ulcerans group
Accessions
- Primary accessionB2HEM2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 105-123 | Helical | |||
Transmembrane | 146-164 | Helical | |||
Transmembrane | 172-186 | Helical | |||
Transmembrane | 195-209 | Helical | |||
Transmembrane | 342-366 | Helical | |||
Transmembrane | 372-390 | Helical | |||
Transmembrane | 676-695 | Helical | |||
Transmembrane | 705-724 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000455994 | 1-732 | Zinc-exporting P-type ATPase | ||
Expression
Induction
Induced during infection of D.discoideum and by elevated levels of Zn2+.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 29-96 | HMA | |||
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length732
- Mass (Da)77,846
- Last updated2008-06-10 v1
- ChecksumDF612F0A6ADF1878
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000854 EMBL· GenBank· DDBJ | ACC39729.1 EMBL· GenBank· DDBJ | Genomic DNA |