B2HEM2 · CTPC_MYCMM

Function

function

Zn2+ efflux transporter which is involved in detoxification of zinc during infection.

Miscellaneous

Increasing concentrations of Mn2+ does not affect the growth of the wild-type strain, nor that of the deletion mutant, excluding that M.marinum CtpC is a manganese exporter as M.tuberculosis CtpC.

Catalytic activity

Features

Showing features for active site, binding site.

1732100200300400500600700
Type
IDPosition(s)Description
Active site4234-aspartylphosphate intermediate
Binding site423Mg2+ (UniProtKB | ChEBI)
Binding site425Mg2+ (UniProtKB | ChEBI)
Binding site625Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncopper ion binding
Molecular FunctionP-type divalent copper transporter activity
Biological Processcopper ion homeostasis
Biological Processzinc ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc-exporting P-type ATPase
  • EC number
  • Alternative names
    • Zn(2+) efflux pump CtpC

Gene names

    • Name
      ctpC
    • Ordered locus names
      MMAR_1271

Organism names

Accessions

  • Primary accession
    B2HEM2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane105-123Helical
Transmembrane146-164Helical
Transmembrane172-186Helical
Transmembrane195-209Helical
Transmembrane342-366Helical
Transmembrane372-390Helical
Transmembrane676-695Helical
Transmembrane705-724Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Deletion of the gene leads to growth inhibition in the presence of elevated levels of Zn2+, but not Mn2+ or Cu2+ (PubMed:33531393).
Deletion mutant shows strongly attenuated intracellular growth during D.discoideum infection (PubMed:33531393).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004559941-732Zinc-exporting P-type ATPase

Expression

Induction

Induced during infection of D.discoideum and by elevated levels of Zn2+.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-96HMA

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    732
  • Mass (Da)
    77,846
  • Last updated
    2008-06-10 v1
  • Checksum
    DF612F0A6ADF1878
MTLAIVKEVPAGADGDDTTDLVVLSDAAGRMRVRADWVRGNSRRAVAVEEAVAKQDGVRVVHAYPRTGSVVVWYSPRRCDRAAVLEAIGGAKHVAAELIPARAPHSTEIRNTDVLRMVIGGAALALLGVRRYVFARPPLLGPSGRMVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAATIASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWIRLTDGPEAGTEVQVPIDSVQIGDEVVVHDHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVAGATVHAGSVVVRGRLVVRAQAVGNQTTIGRIITRVEEAQNDRAPIQTVGENFSRRFVPTSFIVSAITLLVTGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQAGRVDAIVFDKTGTLTVGRPVVTNIIAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRSTEERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLESEQVKVSKKASEWVGKLRQQAETPLLLAVDGTLVGLISLRDEVRPEAAEVLTKLRDNGVRRIVMLTGDHPDIAKVVAEELGIDEWRAEVMPEDKLEVVRDLQDEGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVAVETADVALANDDLHRLLDVRDLGGRAVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAAILHNASSVAVVANSSRLIRYRLE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000854
EMBL· GenBank· DDBJ
ACC39729.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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