B2GV36 · S22AD_RAT

  • Protein
    Solute carrier family 22 member 13
  • Gene
    Slc22a13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Anion antiporter that mediates the transport of nicotinate (PubMed:35144162).
Possibly involved in nicotinate intestinal reabsorption (By similarity).

Caution

In contrast with human ortholog, not able to transport urate and orotate (PubMed:35144162).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentplasma membrane
Molecular Functionnicotinate transmembrane transporter activity
Molecular Functionurate transmembrane transporter activity
Biological Processnegative regulation of fatty acid metabolic process
Biological Processnicotinate transport
Biological Processpositive regulation of T cell mediated cytotoxicity directed against tumor cell target
Biological Processurate transport

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 22 member 13
  • Alternative names
    • Organic anion transporter 10
      (OAT10
      )
    • Organic cation transporter-like 3
      (ORCTL-3
      )

Gene names

    • Name
      Slc22a13

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    B2GV36

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-43Helical
Transmembrane143-163Helical
Transmembrane168-188Helical
Transmembrane196-216Helical
Transmembrane227-247Helical
Transmembrane252-272Helical
Transmembrane333-353Helical
Transmembrane355-375Helical
Transmembrane394-412Helical
Transmembrane417-439Helical
Transmembrane453-473Helical
Transmembrane479-499Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004564641-551Solute carrier family 22 member 13

Post-translational modification

Glycosylated.

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region515-537Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    551
  • Mass (Da)
    60,691
  • Last updated
    2008-06-10 v1
  • Checksum
    0A0EDFF2BF2DA3CC
MAQFAQVMAEVGDFGRFQVRLTILMGIPNFLSAFFVFSQVFMVLDEAHYCSVSWVKNHTFNLSAAEQLAVSIPNDTAGRPESCLMFRPPPDNASLEDILSHRFNETQACDSGWDYPENRPPSLKNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLLLSGIASMATAFVSSFELYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFALGLMALAGLAYGVRNWRLLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLNQLVPEKTGPSGNALDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVEVPARLSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVATALAVVGKFASSAAFTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETRGQTLKDTLQDLEQGQPPRSYKTAPQRKDVEASGRTSSARVAVVRSSYF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A3J4A0A8I6A3J4_RATLOC120094289521
A0A8I6A5H4A0A8I6A5H4_RATSlc22a13562

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC166511
EMBL· GenBank· DDBJ
AAI66511.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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