B2GV36 · S22AD_RAT
- ProteinSolute carrier family 22 member 13
- GeneSlc22a13
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids551 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Anion antiporter that mediates the transport of nicotinate (PubMed:35144162).
Possibly involved in nicotinate intestinal reabsorption (By similarity).
Possibly involved in nicotinate intestinal reabsorption (By similarity).
Catalytic activity
- a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out)a carboxylate (out)CHEBI:29067
+ nicotinate (in)CHEBI:32544= a carboxylate (in)CHEBI:29067+ nicotinate (out)CHEBI:32544
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | nicotinate transmembrane transporter activity | |
Molecular Function | urate transmembrane transporter activity | |
Biological Process | negative regulation of fatty acid metabolic process | |
Biological Process | nicotinate transport | |
Biological Process | positive regulation of T cell mediated cytotoxicity directed against tumor cell target | |
Biological Process | urate transport |
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 22 member 13
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB2GV36
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 23-43 | Helical | ||||
Sequence: ILMGIPNFLSAFFVFSQVFMV | ||||||
Transmembrane | 143-163 | Helical | ||||
Sequence: VFMAGLLVGALVFGPVCDWIG | ||||||
Transmembrane | 168-188 | Helical | ||||
Sequence: LLMQLLLSGIASMATAFVSSF | ||||||
Transmembrane | 196-216 | Helical | ||||
Sequence: FALATANAGFLLSSNVLLSEW | ||||||
Transmembrane | 227-247 | Helical | ||||
Sequence: VLAQSNFALGLMALAGLAYGV | ||||||
Transmembrane | 252-272 | Helical | ||||
Sequence: LLQIIGTTPIFLLVFYFWVLP | ||||||
Transmembrane | 333-353 | Helical | ||||
Sequence: VTLILIAVWFVDSLLYYGLGF | ||||||
Transmembrane | 355-375 | Helical | ||||
Sequence: VGDFGLDIYLTQVIFGVVEVP | ||||||
Transmembrane | 394-412 | Helical | ||||
Sequence: LCTLTLAGVMCVIIIFIPG | ||||||
Transmembrane | 417-439 | Helical | ||||
Sequence: VATALAVVGKFASSAAFTISYVY | ||||||
Transmembrane | 453-473 | Helical | ||||
Sequence: MGLVSIFSRVGGIITPLVMLL | ||||||
Transmembrane | 479-499 | Helical | ||||
Sequence: AIPMLIFGSLPIGAGLLCALL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000456464 | 1-551 | Solute carrier family 22 member 13 | |||
Sequence: MAQFAQVMAEVGDFGRFQVRLTILMGIPNFLSAFFVFSQVFMVLDEAHYCSVSWVKNHTFNLSAAEQLAVSIPNDTAGRPESCLMFRPPPDNASLEDILSHRFNETQACDSGWDYPENRPPSLKNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLLLSGIASMATAFVSSFELYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFALGLMALAGLAYGVRNWRLLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLNQLVPEKTGPSGNALDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVEVPARLSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVATALAVVGKFASSAAFTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETRGQTLKDTLQDLEQGQPPRSYKTAPQRKDVEASGRTSSARVAVVRSSYF |
Post-translational modification
Glycosylated.
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 515-537 | Disordered | ||||
Sequence: EQGQPPRSYKTAPQRKDVEASGR |
Sequence similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length551
- Mass (Da)60,691
- Last updated2008-06-10 v1
- Checksum0A0EDFF2BF2DA3CC
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6A3J4 | A0A8I6A3J4_RAT | LOC120094289 | 521 | ||
A0A8I6A5H4 | A0A8I6A5H4_RAT | Slc22a13 | 562 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC166511 EMBL· GenBank· DDBJ | AAI66511.1 EMBL· GenBank· DDBJ | mRNA |