B2GGU8 · HIS1_KOCRD
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids281 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Kocuria
Accessions
- Primary accessionB2GGU8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000092736 | 1-281 | ATP phosphoribosyltransferase | |||
Sequence: MLRVAVPNKGALSESAITMLTEAGYRQRRSSRELVLVDNDNGVEFFYLRPRDIAIYVGGGTLDLGITGRDLLLDSGAEAAEELCLDFARSTFRLAGPLGQFSSVQDLQGKRIATSYQVLLERHLAEQGVDAEVVRLDGAVESSIRLGVADAIADVVETGNTLRAAGLEIFDEPIMTSEALLIRRGDEPEPEGLSVLRRRLQGVLVARQYVMMDYDIREELLPAATEITPGMEGPTISPLGRDGAVAVRSMVRKADTNKVMDALYEVGARAILVSPIQAARI |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)30,485
- Last updated2008-06-10 v1
- ChecksumBAD029C3275E4CA6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP009152 EMBL· GenBank· DDBJ | BAG29521.1 EMBL· GenBank· DDBJ | Genomic DNA |