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B2GAT5 · UPP_LIMF3

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site795-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1045-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site131-1395-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site196uracil (UniProtKB | ChEBI)
Binding site201-203uracil (UniProtKB | ChEBI)
Binding site2025-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      LAF_0431

Organism names

Accessions

  • Primary accession
    B2GAT5

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001391371-211Uracil phosphoribosyltransferase

Structure

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    23,338
  • Last updated
    2008-06-10 v1
  • MD5 Checksum
    FA6DAB2EA1536BE01CC2960C02962F31
MGKFEVLDHPLIQHKLTMIRDKRVGTKVFRETVKEISTLMAYEVSRNMPLKDVEVETPIAKTTQKELAGKKVAIIPILRAGLGMVDGMTELIPAAKIGFIGMYRDEETLKPHEYFVKLPNDITERQLFIVDPMLATGGSAVMAIEALKKRGCQEKNMKFACLVAAPEGVKAVQEAFPDVDIYTAGLDERLNEDGYIVPGLGDAGDRLFGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008937
EMBL· GenBank· DDBJ
BAG26767.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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