B2CZB8 · B2CZB8_DANRE
- ProteinCalcium-transporting ATPase
- Geneatp2b2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1253 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Catalytic activity
- ATP + Ca2+(in) + H2O = ADP + Ca2+(out) + H+ + phosphate
CHEBI:30616 + Ca2+ (in)CHEBI:29108+ CHEBI:15377 = CHEBI:456216 + Ca2+ (out)CHEBI:29108+ CHEBI:15378 + CHEBI:43474
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | P-type calcium transporter activity | |
Molecular Function | PDZ domain binding | |
Biological Process | regulation of cytosolic calcium ion concentration |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-transporting ATPase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB2CZB8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 411-429 | Helical | ||||
Sequence: AGLVMSAITVIILVLYFAI | ||||||
Transmembrane | 454-480 | Helical | ||||
Sequence: FFIIGVTVLVVAVPEGLPLAVTISLAY | ||||||
Transmembrane | 889-910 | Helical | ||||
Sequence: FLQFQLTVNVVAVIVAFTGACI | ||||||
Transmembrane | 966-984 | Helical | ||||
Sequence: ILGHGVYQLVIIFSLLFVG | ||||||
Transmembrane | 1004-1022 | Helical | ||||
Sequence: EHYTIIFNTFVMMQLFNEI | ||||||
Transmembrane | 1042-1062 | Helical | ||||
Sequence: IFCSIVVGTFAIQIVIVQFGG |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 46-120 | Cation-transporting P-type ATPase N-terminal | ||||
Sequence: DYGGTEGLCQRLKTSPTEGLAGLATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSF | ||||||
Compositional bias | 291-306 | Basic and acidic residues | ||||
Sequence: GEEEEKKEKKGQALED | ||||||
Region | 291-314 | Disordered | ||||
Sequence: GEEEEKKEKKGQALEDGHPLPDCS | ||||||
Compositional bias | 342-359 | Polar residues | ||||
Sequence: NGKMQDGNMENNQTKVKK | ||||||
Region | 342-392 | Disordered | ||||
Sequence: NGKMQDGNMENNQTKVKKQDGAAAMEMQPLKSAEGGETEEKEKKKTSVSKK | ||||||
Compositional bias | 374-392 | Basic and acidic residues | ||||
Sequence: AEGGETEEKEKKKTSVSKK | ||||||
Region | 1205-1253 | Disordered | ||||
Sequence: AARKNSSQPASPNKNNNAIDSGINLTTDTSKSAASSSPGSPLHSLETSL | ||||||
Compositional bias | 1208-1253 | Polar residues | ||||
Sequence: KNSSQPASPNKNNNAIDSGINLTTDTSKSAASSSPGSPLHSLETSL |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,253
- Mass (Da)137,867
- Last updated2008-05-20 v1
- Checksum395007E8AA63F0BC
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9QD45 | A0A8M9QD45_DANRE | atp2b2 | 1212 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 291-306 | Basic and acidic residues | ||||
Sequence: GEEEEKKEKKGQALED | ||||||
Compositional bias | 342-359 | Polar residues | ||||
Sequence: NGKMQDGNMENNQTKVKK | ||||||
Compositional bias | 374-392 | Basic and acidic residues | ||||
Sequence: AEGGETEEKEKKKTSVSKK | ||||||
Compositional bias | 1208-1253 | Polar residues | ||||
Sequence: KNSSQPASPNKNNNAIDSGINLTTDTSKSAASSSPGSPLHSLETSL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF591990 EMBL· GenBank· DDBJ | ABU68840.1 EMBL· GenBank· DDBJ | mRNA | ||
EU559282 EMBL· GenBank· DDBJ | ACB45511.1 EMBL· GenBank· DDBJ | mRNA |