B2B5H6 · B2B5H6_PODAN
- ProteinSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids332 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 50-53 | CoA (UniProtKB | ChEBI) | |||
Binding site | 76 | CoA (UniProtKB | ChEBI) | |||
Binding site | 129-131 | CoA (UniProtKB | ChEBI) | |||
Binding site | 193 | substrate; ligand shared with subunit beta | |||
Active site | 285 | Tele-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex (ADP-forming) | |
Molecular Function | nucleotide binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | succinate-CoA ligase (GDP-forming) activity | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Podosporaceae > Podospora > Podospora anserina
Accessions
- Primary accessionB2B5H6
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 37-133 | CoA-binding | |||
Sequence similarities
Belongs to the succinate/malate CoA ligase alpha subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)34,649
- Last updated2008-05-20 v1
- MD5 Checksum00EAAC1040870D0B8C0285C50D1D5CAE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU640366 EMBL· GenBank· DDBJ | CAP73051.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO904937 EMBL· GenBank· DDBJ | CDP25451.1 EMBL· GenBank· DDBJ | Genomic DNA |