B2AH54 · PYRC_CUPTR

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14Zn2+ 1 (UniProtKB | ChEBI)
Binding site16Zn2+ 1 (UniProtKB | ChEBI)
Binding site16-18substrate
Binding site42substrate
Binding site100Zn2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site100Zn2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site137substrate
Binding site137Zn2+ 2 (UniProtKB | ChEBI)
Binding site175Zn2+ 2 (UniProtKB | ChEBI)
Binding site220substrate
Active site248
Binding site248Zn2+ 1 (UniProtKB | ChEBI)
Binding site252substrate
Binding site264substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      RALTA_A0435

Organism names

Accessions

  • Primary accession
    B2AH54

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_10001000391-344Dihydroorotase
Modified residue100N6-carboxylysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    37,579
  • Last updated
    2008-05-20 v1
  • Checksum
    44B55466A1D3DDD8
MTQKLTITRPDDWHLHLRDGAALAAVLPDTARQFARAIVMPNLKPPVTTVAQAQAYRARILAALPAGMQFEPLMTLYLTDNTGPEEIAAARASGFVHGVKLYPAGATTNSDAGVTDIRRCYPALEAMQRAGLPLLVHGEVTDPAIDIFDREAVFIERVMTPLRRDMPELKVVFEHITTKDAAQYVRDASGPVGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHREALVAAATSGSERFFLGTDSAPHARGLKEHACGCAGCYTALHAMELYAEAFDAAGALDKLEAFASFNGPAFYGLPRNTGTLTLEREDWELPAELPYGDTTLVPLRGGETLRWKAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU633749
EMBL· GenBank· DDBJ
CAP63103.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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