B2A946 · B2A946_PODAN
- ProteinATP-dependent (S)-NAD(P)H-hydrate dehydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalytic activity
- (6S)-NADHX + ATP = ADP + phosphate + NADH + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 133 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 186-192 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: NVVEFER | ||||||
Binding site | 228-232 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KGGKD | ||||||
Binding site | 247-256 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GGKKRSGGQG | ||||||
Binding site | 257 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent NAD(P)H-hydrate dehydratase activity | |
Biological Process | metabolite repair | |
Biological Process | nicotinamide nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent (S)-NAD(P)H-hydrate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Podosporaceae > Podospora > Podospora anserina
Accessions
- Primary accessionB2A946
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-319 | YjeF C-terminal | ||||
Sequence: ILGRVRQLIPPMLERFHKGQMGRVAVIGGSEDYTGAPYFSAMASARLGCDLSHVICTPTAATVIKTYSPNLMVHPLMRSLPSSPAKPAGEDSDPSTASKHDTDPSEIASRIIPLLSRLHVLVIGPGLGRDPLMQKTVALVIQAAKKQNIPMVLDADALLLICNDPDLVRGYQEAVLTPNVVEFERLAKALNIEKEVAKEGKETDRVERLARELGGVMVLQKGGKDHLSNGTVTYSVDLEGGKKRSGGQGDTLTGSIATFLGWRKAYHEGLWDVKHKMKEEETAGLAVFGGSVITRGMLPPCLCQKRPQPSGQ | ||||||
Region | 85-111 | Disordered | ||||
Sequence: RSLPSSPAKPAGEDSDPSTASKHDTDP |
Sequence similarities
Belongs to the NnrD/CARKD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)34,369
- Last updated2008-05-20 v1
- ChecksumDAF6C8A24289EF59
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU633438 EMBL· GenBank· DDBJ | CAP60547.1 EMBL· GenBank· DDBJ | Genomic DNA |