B2A946 · B2A946_PODAN

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site133(6S)-NADPHX (UniProtKB | ChEBI)
Binding site186-192(6S)-NADPHX (UniProtKB | ChEBI)
Binding site228-232ATP (UniProtKB | ChEBI)
Binding site247-256ATP (UniProtKB | ChEBI)
Binding site257(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase

Gene names

    • ORF names
      PODANS_1_8380

Organism names

Accessions

  • Primary accession
    B2A946

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain8-319YjeF C-terminal
Region85-111Disordered

Sequence similarities

Belongs to the NnrD/CARKD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    34,369
  • Last updated
    2008-05-20 v1
  • Checksum
    DAF6C8A24289EF59
MSSATKEILGRVRQLIPPMLERFHKGQMGRVAVIGGSEDYTGAPYFSAMASARLGCDLSHVICTPTAATVIKTYSPNLMVHPLMRSLPSSPAKPAGEDSDPSTASKHDTDPSEIASRIIPLLSRLHVLVIGPGLGRDPLMQKTVALVIQAAKKQNIPMVLDADALLLICNDPDLVRGYQEAVLTPNVVEFERLAKALNIEKEVAKEGKETDRVERLARELGGVMVLQKGGKDHLSNGTVTYSVDLEGGKKRSGGQGDTLTGSIATFLGWRKAYHEGLWDVKHKMKEEETAGLAVFGGSVITRGMLPPCLCQKRPQPSGQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU633438
EMBL· GenBank· DDBJ
CAP60547.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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