B1PHI7 · B1PHI7_9ALPC

  • Protein
    Replicase polyprotein 1a
  • Gene
    ORF1a
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA binding
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processviral genome replication
Biological Processviral protein processing
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Replicase polyprotein 1a
  • Alternative names
    • ORF1a polyprotein

Gene names

    • Name
      ORF1a

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AFCD307
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Alphacoronavirus > Minunacovirus > Miniopterus bat coronavirus 1

Accessions

  • Primary accession
    B1PHI7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2180-2195Helical
Transmembrane2239-2259Helical
Transmembrane2324-2347Helical
Transmembrane2735-2757Helical
Transmembrane2993-3014Helical
Transmembrane3020-3040Helical
Transmembrane3047-3066Helical
Transmembrane3078-3100Helical
Transmembrane3512-3531Helical
Transmembrane3543-3560Helical
Transmembrane3567-3586Helical
Transmembrane3606-3628Helical
Transmembrane3640-3667Helical
Transmembrane3673-3691Helical
Transmembrane3703-3726Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain2-109CoV Nsp1 globular
Domain112-356CoV Nsp2 N-terminal
Domain893-989Ubiquitin-like
Domain1181-1431Peptidase C16
Domain1433-1600Macro
Domain1848-1903Ubiquitin-like
Domain1910-2174Peptidase C16
Domain2251-23153Ecto
Region2389-2479Y1
Domain2389-2728CoV Nsp3 Y
Region2393-2406ZF1
Region2439-2449ZF2
Region2480-2728CoV-Y
Region2627-2728Y4
Domain3108-3203Nsp4C
Domain3204-3505Peptidase C30
Domain3785-3867RdRp Nsp7 cofactor
Domain3868-4061RdRp Nsp8 cofactor
Domain4062-4171Nsp9 ssRNA-binding
Domain4172-4311ExoN/MTase coactivator

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,324
  • Mass (Da)
    476,631
  • Last updated
    2008-04-29 v1
  • Checksum
    4C75D27EBA9CF1B6

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU420137
EMBL· GenBank· DDBJ
ACA52155.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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