B1H1H3 · ZDH21_DANRE
- ProteinPalmitoyltransferase ZDHHC21
- Genezdhhc21
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids263 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates.
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 120 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | plasma membrane | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | peptidyl-L-cysteine S-palmitoylation | |
Biological Process | protein targeting to membrane |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC21
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB1H1H3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-4 | Cytoplasmic | ||||
Sequence: MKMR | ||||||
Transmembrane | 5-25 | Helical | ||||
Sequence: LHFVVDPMGWFCMSMVFFVWI | ||||||
Topological domain | 26-44 | Extracellular | ||||
Sequence: YNSFLIPKLVLLPHYAEGH | ||||||
Transmembrane | 45-65 | Helical | ||||
Sequence: ITAEPVICYYLASLLCFSALF | ||||||
Topological domain | 66-131 | Cytoplasmic | ||||
Sequence: RASTTDPGKLAQDPKIPLAERDNWELCNKCNMMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDN | ||||||
Transmembrane | 132-152 | Helical | ||||
Sequence: HWLFLQLCFYTQVLSFYTLVL | ||||||
Topological domain | 153-181 | Extracellular | ||||
Sequence: DFCQYYYFLPLSSVDQADFAVHHELALLR | ||||||
Transmembrane | 182-202 | Helical | ||||
Sequence: VSCFMGLIMFGGISSLFYTQV | ||||||
Topological domain | 203-263 | Cytoplasmic | ||||
Sequence: KGILTDTTTIEKMSHLTEEVPRRPWQQAMAEVFGTRWKVLWFLPFRSRHPLKLNLTIRSHV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000451163 | 1-263 | Palmitoyltransferase ZDHHC21 | |||
Sequence: MKMRLHFVVDPMGWFCMSMVFFVWIYNSFLIPKLVLLPHYAEGHITAEPVICYYLASLLCFSALFRASTTDPGKLAQDPKIPLAERDNWELCNKCNMMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCFYTQVLSFYTLVLDFCQYYYFLPLSSVDQADFAVHHELALLRVSCFMGLIMFGGISSLFYTQVKGILTDTTTIEKMSHLTEEVPRRPWQQAMAEVFGTRWKVLWFLPFRSRHPLKLNLTIRSHV |
Keywords
- PTM
Proteomic databases
Expression
Developmental stage
Probably maternally supplied, the zygotic expression becomes significant at 4.0 hpf and remains constant until 24 hpf.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 90-140 | DHHC | ||||
Sequence: ELCNKCNMMRPKRSHHCSRCGHCVRRMDHHCPWINNCVGEDNHWLFLQLCF |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)30,916
- Last updated2020-10-07 v2
- Checksum70603A619F936071
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 254 | in Ref. 1; AAI60605 | ||||
Sequence: K → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC160605 EMBL· GenBank· DDBJ | AAI60605.1 EMBL· GenBank· DDBJ | mRNA | ||
CABZ01067984 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR536621 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |