B1H1F5 · B1H1F5_XENTR
- ProteinInterleukin-1 receptor-associated kinase 4
- Geneirak4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids457 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | innate immune response | |
Biological Process | positive regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor-associated kinase 4
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionB1H1F5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Interaction
Subunit
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 179-450 | Protein kinase | ||||
Sequence: SEGGNKLGEGGFGVVFKGEIKEKIVAVKKLTELVDASIQDLTCQFEQEIKIMGKCQHENLVKLLGYSKDGDQYCLIYTYMPNGSLLDRLACLNDTPPISWVLRCNIAYGTANGINYLHENSHVHRDIKSANILLDDTLVPKISDFGLSRATGQFSKTMMTERIVGTTAYMAPEALRGEITIKSDIFSFGVVLLEIISGLAPVDENRSPSLLLDIKEEIEEEEKTIEEYTDKKMGDVEPNTLKKMYTVASQCLNQMKNRRPVITRVLQNLEDI |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length457
- Mass (Da)50,888
- Last updated2008-04-29 v1
- ChecksumF70477EEDEC65676
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A803KGP4 | A0A803KGP4_XENTR | irak4 | 457 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC160587 EMBL· GenBank· DDBJ | AAI60587.1 EMBL· GenBank· DDBJ | mRNA |