B1H1F5 · B1H1F5_XENTR

Function

function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site206ATP (UniProtKB | ChEBI)
Binding site207ATP (UniProtKB | ChEBI)
Active site304Proton acceptor
Binding site306ATP (UniProtKB | ChEBI)
Binding site306-308ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionprotein serine/threonine kinase activity
Biological Processcell surface receptor signaling pathway
Biological Processinnate immune response
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of defense response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-1 receptor-associated kinase 4
  • EC number

Gene names

    • Name
      irak4
    • Synonyms
      ipd1
      , irak-4
      , ny-ran-64
      , ny-ren-64
      , ren64

Organism names

Accessions

  • Primary accession
    B1H1F5
  • Secondary accessions
    • F7BTN5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain179-450Protein kinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    50,888
  • Last updated
    2008-04-29 v1
  • Checksum
    F70477EEDEC65676
MSKTVTPSTYVRNLSHGMHRQLADLLDPQEGWKKIAVNIMKPSGDARYSQFHIRRFEGTVQMGKSPTCELLYDWGTTNCTVQDLKDLLQKNGFSAAASLLLPAKNTENVNASTRPVSSAINAPCEMSAAEVIDTCNPHTYQSKGPEENEVDDFDDMGIGRFSFTEVKQSTNNFDIRPVSEGGNKLGEGGFGVVFKGEIKEKIVAVKKLTELVDASIQDLTCQFEQEIKIMGKCQHENLVKLLGYSKDGDQYCLIYTYMPNGSLLDRLACLNDTPPISWVLRCNIAYGTANGINYLHENSHVHRDIKSANILLDDTLVPKISDFGLSRATGQFSKTMMTERIVGTTAYMAPEALRGEITIKSDIFSFGVVLLEIISGLAPVDENRSPSLLLDIKEEIEEEEKTIEEYTDKKMGDVEPNTLKKMYTVASQCLNQMKNRRPVITRVLQNLEDIKNLVSSS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A803KGP4A0A803KGP4_XENTRirak4457

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC160587
EMBL· GenBank· DDBJ
AAI60587.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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