B1B507 · B1B507_MOUSE

  • Protein
    L-selectin
  • Gene
    Sell
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site.

138750100150200250300350
TypeIDPosition(s)Description
Binding site118Ca2+ (UniProtKB | ChEBI)
Binding site120Ca2+ (UniProtKB | ChEBI)
Binding site126Ca2+ (UniProtKB | ChEBI)
Binding site143Ca2+ (UniProtKB | ChEBI)
Binding site144Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionoligosaccharide binding
Molecular Functionprotease binding
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processleukocyte tethering or rolling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    L-selectin
  • Alternative names
    • CD62 antigen-like family member L
    • Leukocyte adhesion molecule 1
    • Leukocyte-endothelial cell adhesion molecule 1
    • Lymph node homing receptor

Gene names

    • Name
      Sell

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B1B507

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane334-355Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-38
ChainPRO_501508704439-387L-selectin
Disulfide bond57↔155
Glycosylation60N-linked (GlcNAc...) asparagine
Glycosylation104N-linked (GlcNAc...) asparagine
Disulfide bond128↔147
Disulfide bond160↔171
Disulfide bond165↔180
Glycosylation177N-linked (GlcNAc...) asparagine
Disulfide bond182↔191
Disulfide bond197↔241
Disulfide bond227↔254
Disulfide bond259↔303
Disulfide bond289↔316

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-156C-type lectin
Domain156-192EGF-like
Domain195-256Sushi
Domain257-318Sushi

Sequence similarities

Belongs to the selectin/LECAM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    387
  • Mass (Da)
    43,585
  • Last updated
    2008-04-29 v1
  • Checksum
    84611E373FC80E8A
MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHCWTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLKKGRTNAPATGPQSAAVLRCALPHLSTFI

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P18337LYAM1_MOUSESell372
A0A0A6YW25A0A0A6YW25_MOUSESell100
Q3TCF3Q3TCF3_MOUSESell336

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB353768
EMBL· GenBank· DDBJ
BAG12831.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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