B1B507 · B1B507_MOUSE
- ProteinL-selectin
- GeneSell
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids387 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | oligosaccharide binding | |
Molecular Function | protease binding | |
Biological Process | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | |
Biological Process | leukocyte tethering or rolling |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameL-selectin
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionB1B507
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 334-355 | Helical | ||||
Sequence: LFIPVAVMVTAFSGLAFLIWLA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-38 | |||||
Sequence: MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHC | ||||||
Chain | PRO_5015087044 | 39-387 | L-selectin | |||
Sequence: WTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLKKGRTNAPATGPQSAAVLRCALPHLSTFI | ||||||
Disulfide bond | 57↔155 | |||||
Sequence: CKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALC | ||||||
Glycosylation | 60 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 104 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 128↔147 | |||||
Sequence: CVEIYIKRERDSGKWNDDAC | ||||||
Disulfide bond | 160↔171 | |||||
Sequence: CQPGSCNGRGEC | ||||||
Disulfide bond | 165↔180 | |||||
Sequence: CNGRGECVETINNHTC | ||||||
Glycosylation | 177 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 182↔191 | |||||
Sequence: CDAGYYGPQC | ||||||
Disulfide bond | 197↔241 | |||||
Sequence: CEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQC | ||||||
Disulfide bond | 227↔254 | |||||
Sequence: CSEGRELLGTAETQCGASGNWSSPEPIC | ||||||
Disulfide bond | 259↔303 | |||||
Sequence: CEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQC | ||||||
Disulfide bond | 289↔316 | |||||
Sequence: CSEGRELLGTAETQCGASGNWSSPEPIC |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-156 | C-type lectin | ||||
Sequence: HGTHCWTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCY | ||||||
Domain | 156-192 | EGF-like | ||||
Sequence: YTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQ | ||||||
Domain | 195-256 | Sushi | ||||
Sequence: VQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQV | ||||||
Domain | 257-318 | Sushi | ||||
Sequence: VQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQE |
Sequence similarities
Belongs to the selectin/LECAM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length387
- Mass (Da)43,585
- Last updated2008-04-29 v1
- Checksum84611E373FC80E8A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P18337 | LYAM1_MOUSE | Sell | 372 | ||
A0A0A6YW25 | A0A0A6YW25_MOUSE | Sell | 100 | ||
Q3TCF3 | Q3TCF3_MOUSE | Sell | 336 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB353768 EMBL· GenBank· DDBJ | BAG12831.1 EMBL· GenBank· DDBJ | mRNA |