B1AXF5 · B1AXF5_MOUSE

  • Protein
    Alkaline phosphatase, tissue-nonspecific isozyme
  • Gene
    Alpl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Catalytic activity

  • ADP + H2O = AMP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • AMP + H2O = adenosine + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O = ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • H2O + N-phosphocreatine = creatine + phosphate
    This reaction proceeds in the forward direction.
    EC:3.9.1.1 (UniProtKB | ENZYME | Rhea)
  • H2O + phosphoethanolamine = ethanolamine + phosphate
    This reaction proceeds in the forward direction.
  • H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal
    This reaction proceeds in the forward direction.
  • a phosphate monoester + H2O = an alcohol + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.1 (UniProtKB | ENZYME | Rhea)
  • diphosphate + H2O = H+ + 2 phosphate
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site60Mg2+ (UniProtKB | ChEBI)
Binding site60Zn2+ 2 (UniProtKB | ChEBI)
Active site110Phosphoserine intermediate

GO annotations

AspectTerm
Cellular Componentmitochondrial intermembrane space
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionalkaline phosphatase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alkaline phosphatase, tissue-nonspecific isozyme
  • EC number
  • Alternative names
    • Alkaline phosphatase liver/bone/kidney isozyme
    • Phosphoamidase
    • Phosphocreatine phosphatase

Gene names

    • Name
      Alpl

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    B1AXF5

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Extracellular vesicle membrane
; Lipid-anchor, GPI-anchor
Membrane
; Lipid-anchor, GPI-anchor
Mitochondrion membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_500840994418-157Alkaline phosphatase, tissue-nonspecific isozyme

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the alkaline phosphatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    157
  • Mass (Da)
    17,095
  • Last updated
    2016-10-05 v8
  • Checksum
    2AF871099B292CDF
MISPFLVLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDA

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P09242PPBT_MOUSEAlpl524
E9Q7P8E9Q7P8_MOUSEAlpl216
B1AXF6B1AXF6_MOUSEAlpl98

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue157

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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