rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice.Chang H.C., Lee Y.J., Javed S., Haque M., Chang Y.T., Lin Y.C., Oram C., Huang W.H.View abstractCategoriesFunction, ExpressionSourceMGI: 103291PubMedEurope PMCJ Biol Chem 299:102728-102728 (2023)Mapped to5
Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.Javed S., Lee Y.J., Xu J., Huang W.H.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCHum Mol Genet 31:275-288 (2021)Mapped to16
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.Luo L., Ambrozkiewicz M.C., Benseler F., Chen C., Dumontier E., Falkner S., Furlanis E., Gomez A.M., Hoshina N.[...], Craig A.M.View abstractCategoriesFunctionSourceMGI: 103291PubMedEurope PMCNeuron 106:37-65.e5 (2020)Mapped to99+
Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome.Huang W.H., Wang D.C., Allen W.E., Klope M., Hu H., Shamloo M., Luo L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCProc Natl Acad Sci U S A 115:10744-10749 (2018)Mapped to15
<i>Rai1</i> frees mice from the repression of active wake behaviors by light.Diessler S., Kostic C., Arsenijevic Y., Kawasaki A., Franken P.View abstractCategoriesFunctionSourceMGI: 103291PubMedEurope PMCElife 6:e23292-e23292 (2017)Mapped to5
Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.Huang W.H., Guenthner C.J., Xu J., Nguyen T., Schwarz L.A., Wilkinson A.W., Gozani O., Chang H.Y., Shamloo M., Luo L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCNeuron 92:392-406 (2016)Mapped to47
Dietary regimens modify early onset of obesity in mice haploinsufficient for Rai1.Alaimo J.T., Hahn N.C., Hahn N.H., Mullegama S.V., Elsea S.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCPLoS One 9:e105077-e105077 (2014)Mapped to5
Correct developmental expression level of Rai1 in forebrain neurons is required for control of body weight, activity levels and learning and memory.Cao L., Molina J., Abad C., Carmona-Mora P., Cardenas Oyarzo A., Young J.I., Walz K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCHum Mol Genet 23:1771-1782 (2014)Mapped to5
The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.Savino M.T., Ulivieri C., Emmi G., Prisco D., De Falco G., Ortensi B., Beccastrini E., Emmi L., Pelicci G.[...], Baldari C.T.View abstractCategoriesFunctionSourceMGI: 103291PubMedEurope PMCJ Leukoc Biol 93:549-559 (2013)Mapped to10
Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity.Williams S.R., Zies D., Mullegama S.V., Grotewiel M.S., Elsea S.H.View abstractCategoriesFunctionSourceMGI: 103291PubMedEurope PMCAm. J. Hum. Genet. 90:941-949 (2012)Cited in2Mapped to17
Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome.Burns B., Schmidt K., Williams S.R., Kim S., Girirajan S., Elsea S.H.View abstractCategoriesFunctionSourceMGI: 103291PubMedEurope PMCHum Mol Genet 19:4026-4042 (2010)Mapped to12
Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgenic mice.Girirajan S., Elsea S.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCMamm Genome 20:247-255 (2009)Mapped to5
Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes.Bi W., Yan J., Shi X., Yuva-Paylor L.A., Antalffy B.A., Goldman A., Yoo J.W., Noebels J.L., Armstrong D.L.[...], Lupski J.R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 103291PubMedEurope PMCHum Mol Genet 16:1802-1813 (2007)Mapped to9