B1AJZ9 · FHAD1_HUMAN
- ProteinForkhead-associated domain-containing protein 1
- GeneFHAD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1412 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameForkhead-associated domain-containing protein 1
- Short namesFHA domain-containing protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB1AJZ9
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_046372 | 763 | in dbSNP:rs12126178 | |||
Sequence: E → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,571 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000349365 | 1-1412 | UniProt | Forkhead-associated domain-containing protein 1 | |||
Sequence: MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRATQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDDARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY | |||||||
Modified residue (large scale data) | 717 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-69 | FHA | ||||
Sequence: TTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRNGTFVNECHI | ||||||
Region | 106-133 | Disordered | ||||
Sequence: MRGPAPWPGPQPPRATQQPNQAPPPSHI | ||||||
Coiled coil | 250-466 | |||||
Sequence: KDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRR | ||||||
Region | 652-688 | Disordered | ||||
Sequence: KAAGASGREGEAERGEARARGEAQSQNQATDGREGGK | ||||||
Coiled coil | 692-963 | |||||
Sequence: EYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDN | ||||||
Compositional bias | 955-971 | Basic and acidic residues | ||||
Sequence: GEIATLKDNDPAPKEER | ||||||
Region | 955-976 | Disordered | ||||
Sequence: GEIATLKDNDPAPKEERPQDPL | ||||||
Coiled coil | 999-1099 | |||||
Sequence: AAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQ | ||||||
Compositional bias | 1086-1105 | Basic and acidic residues | ||||
Sequence: QEKHRLQLNTEKEQKPRKKT | ||||||
Region | 1086-1110 | Disordered | ||||
Sequence: QEKHRLQLNTEKEQKPRKKTQTCDT | ||||||
Coiled coil | 1141-1169 | |||||
Sequence: SRHEEVIQRQKKALSELRARIKELEKARS | ||||||
Coiled coil | 1292-1360 | |||||
Sequence: DKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQL | ||||||
Region | 1372-1412 | Disordered | ||||
Sequence: QQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY | ||||||
Compositional bias | 1378-1395 | Basic and acidic residues | ||||
Sequence: RKASLKMDQEREMLRKET | ||||||
Compositional bias | 1396-1412 | Polar residues | ||||
Sequence: SSKSSQSLLHSKPSGKY |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
B1AJZ9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,412
- Mass (Da)161,904
- Last updated2008-09-02 v2
- Checksum03BE058D84CF65AA
B1AJZ9-3
- Name3
- Differences from canonical
- 1375-1412: VGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY → MRKLRLRELRGAQVHTAAGKDSWDLTPDPSDPGSPAVCRVGRKCRGARTEKRKRIDTLQLCLQRERQAGPAPPACSLNG
B1AJZ9-4
- Name4
- Differences from canonical
- 758-793: Missing
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_035366 | 758-793 | in isoform 4 | |||
Sequence: Missing | ||||||
Compositional bias | 955-971 | Basic and acidic residues | ||||
Sequence: GEIATLKDNDPAPKEER | ||||||
Sequence conflict | 1004 | in Ref. 2; BAC04913 | ||||
Sequence: I → L | ||||||
Compositional bias | 1086-1105 | Basic and acidic residues | ||||
Sequence: QEKHRLQLNTEKEQKPRKKT | ||||||
Sequence conflict | 1366 | in Ref. 2; BAC04913 | ||||
Sequence: I → V | ||||||
Alternative sequence | VSP_035369 | 1375-1412 | in isoform 3 | |||
Sequence: VGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY → MRKLRLRELRGAQVHTAAGKDSWDLTPDPSDPGSPAVCRVGRKCRGARTEKRKRIDTLQLCLQRERQAGPAPPACSLNG | ||||||
Compositional bias | 1378-1395 | Basic and acidic residues | ||||
Sequence: RKASLKMDQEREMLRKET | ||||||
Compositional bias | 1396-1412 | Polar residues | ||||
Sequence: SSKSSQSLLHSKPSGKY |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL031283 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL158174 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL391094 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK093300 EMBL· GenBank· DDBJ | BAC04126.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK093883 EMBL· GenBank· DDBJ | BAC04242.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK096961 EMBL· GenBank· DDBJ | BAC04913.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |