B1A5Y7 · B1A5Y7_9CALI

Function

function

3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.

Catalytic activity

  • Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.
    EC:3.4.22.66 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

116982004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Active site1037For 3CLpro activity
Active site1061For 3CLpro activity
Active site1146For 3CLpro activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell membrane
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • Nonstructural polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • GII/Leverkusen267/2005/DE
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Norovirus > Norwalk virus

Accessions

  • Primary accession
    B1A5Y7

Subcellular Location

PTM/Processing

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-26Polar residues
Region1-33Disordered
Region47-79Disordered
Domain469-636SF3 helicase
Region850-894Disordered
Compositional bias862-879Basic and acidic residues
Domain1008-1188Peptidase C37
Domain1424-1545RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,698
  • Mass (Da)
    188,990
  • Last updated
    2008-04-08 v1
  • Checksum
    F78B85CB9ACA54E3
MKMASNDATTALGSQTATNDSVNAPPPQKEEVSVLSNVKVGFKKMLGAVPKTPKQREKPVQPPTVSINGVEVEVPPPPPNGEDVVYYNSKNDTVEGLPDLTTVQNEHEHSPYTVPPLSEREHKPAMEPLPGTILEMWDGEFYHYSIYVNNGKALGVHKPPAAISVATIELTPISLYWRPVYTPPYLVHPDTLKGLAGEKFPYTAFSNNCYNFCCWVLDLNDSWLSRKSISRTTGFYKPYQSWNRKPLPTVDDGKIKKVANAVLCALGSLFSKPIKDLLGKLKPLNLLNLLASCDWTFAGIVETVILAAELFNVFWTPPDVSNFIASLIGDFEMQGPEDLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAEMETLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAYMKTLDLEEEKARKLSTKSSSPDIVGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARQLAKTIAGTMAGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNTIKDALTLQELADTCPVTLNCDRIENKGKMFDSDVIIITTNLANPAPLDYVNFEACCRRIDFLVYAEAPEIEKVKKDFPGQPDMWRDHFKPDSSHIRLSLAPQGGFDKNGNTPHGKGTMKTLTQGSLTARVAGLVHERRDEFQFQGDEVQLYNFDANRVSAFRKLAADNKYSLMETMKVGSALKNVKTLEDLKVALRTVKFKECEIIYKGSKYRVSSDGCGNVSVTKVKDMMSQTTNEVHSALIRLRQARARYYISCFQDLIYTLIQVAGASFVVHRISRRFSWERWIKPSEALPEDGQISPTDSAEKWEVEPKDADPEGKKGKNKKGRGRKHTAFSSKGLSDEEYDEFKRVREERGGKYTIEEYLQDRDRFYEEVAVARATEEDFCEEEIAKIRQRVFRPTKKQRKEERSVLGLVTGSEIRKRKPDDFQPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKGVRELFGVDIKQVQIHKSGEFCRFRFPRPIRPDVTGLILEEGAPEGTVCSILVKRPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTIPGDCGCPYIYKRGNDIVVAGVHTAAARGGNTVICATQGPDGEAVLEGGDDKGTYCGAPILSVGKAPKLSTKTKFWRSSPEALPPGTYEPAYLGGKDPRVEKGPSLHQVMRDQLKPFTEPRGKPPNPTVLEEAKKTVMNVLEQTIDPAKPWTYAQACASLDKTTSSGSPHHLKKNDHWNGDSFTGPLADQASKANLMYEQAKHVSPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMVRCARAFGGLLDSMKESCVALPCRVGMNMNEDGPIIFDKHSKYRFHYDADYSRWDSTQQRCILAAAMEVMVKFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWIITLSAMAEVSGLSPEVIQANSCFSFYGDDEIVSTDINLDPAKLTQKLREYGLVPTRPDKTEGPLVITENLHGLTFLRRTVTRDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVISEIKSGGLEFYVPRQEAMFRWMRFSDLSTWEGDRNLAPDGVNEDGVE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-26Polar residues
Compositional bias862-879Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU424333
EMBL· GenBank· DDBJ
ABZ89548.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp