B1A5Y7 · B1A5Y7_9CALI
- ProteinNonstructural polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1698 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1037 | For 3CLpro activity | ||||
Sequence: H | ||||||
Active site | 1061 | For 3CLpro activity | ||||
Sequence: E | ||||||
Active site | 1146 | For 3CLpro activity | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell membrane | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Norovirus > Norwalk virus
Accessions
- Primary accessionB1A5Y7
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Post-translational modification
Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MKMASNDATTALGSQTATNDSVNAPP | ||||||
Region | 1-33 | Disordered | ||||
Sequence: MKMASNDATTALGSQTATNDSVNAPPPQKEEVS | ||||||
Region | 47-79 | Disordered | ||||
Sequence: GAVPKTPKQREKPVQPPTVSINGVEVEVPPPPP | ||||||
Domain | 469-636 | SF3 helicase | ||||
Sequence: LARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARQLAKTIAGTMAGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNTIKDALTLQELADTCPVTLNCDRIENKGKMFDSDVIIITTNLANPAPLDYVNFEACCRRIDFLVYAEAPEIEKVKKDFPGQ | ||||||
Region | 850-894 | Disordered | ||||
Sequence: PEDGQISPTDSAEKWEVEPKDADPEGKKGKNKKGRGRKHTAFSSK | ||||||
Compositional bias | 862-879 | Basic and acidic residues | ||||
Sequence: EKWEVEPKDADPEGKKGK | ||||||
Domain | 1008-1188 | Peptidase C37 | ||||
Sequence: APPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKGVRELFGVDIKQVQIHKSGEFCRFRFPRPIRPDVTGLILEEGAPEGTVCSILVKRPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTIPGDCGCPYIYKRGNDIVVAGVHTAAARGGNTVICATQGPDGEAVLE | ||||||
Domain | 1424-1545 | RdRp catalytic | ||||
Sequence: RFHYDADYSRWDSTQQRCILAAAMEVMVKFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWIITLSAMAEVSGLSPEVIQANSCFSFYGDDEIVSTDINLDPAK |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,698
- Mass (Da)188,990
- Last updated2008-04-08 v1
- ChecksumF78B85CB9ACA54E3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MKMASNDATTALGSQTATNDSVNAPP | ||||||
Compositional bias | 862-879 | Basic and acidic residues | ||||
Sequence: EKWEVEPKDADPEGKKGK |