B0Z8J4 · B0Z8J4_9INFA

Function

function

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.

Activity regulation

The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity. Emergence of amantadine-resistant variants is usually rapid.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell plasma membrane
Cellular Componentmembrane
Cellular Componentvirion membrane
Molecular Functionchannel activity
Molecular Functionproton transmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Matrix protein 2

Gene names

    • Name
      M2

Organism names

  • Taxonomic identifier
  • Strain
    • A/aquatic bird/Korea/CN-2/2004
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus

Accessions

  • Primary accession
    B0Z8J4

Subcellular Location

Virion membrane
Host apical cell membrane
; Single-pass type III membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-47Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region61-86Disordered
Compositional bias67-86Basic and acidic residues

Domain

Cytoplasmic tail plays an important role in virion assembly and morphogenesis.

Sequence similarities

Belongs to the influenza viruses matrix protein M2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    86
  • Mass (Da)
    9,793
  • Last updated
    2008-04-08 v1
  • Checksum
    44A2C9960D27FAB4
MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILDRLFXKCICRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDV

Features

Showing features for compositional bias, non-terminal residue.

TypeIDPosition(s)Description
Compositional bias67-86Basic and acidic residues
Non-terminal residue86

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU301243
EMBL· GenBank· DDBJ
ACA14216.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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