Study identifies BCO2 as a tumor suppressor in prostate cancer which mediates inhibition of NF-kB signaling. Its expression is decreased in human prostate cancer.
a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production.
The gene encoding beta-carotene-9' 10'-oxygenase which cleaves the 9' 10' double bond in beta-carotene into beta-apo-10'-carotenal was cloned and expressed in Escherichia coli.
we found that the third family member beta beta-carotene-9' 10'-oxygenase (BCDO2) is a mitochondrial carotenoid-oxygenase with broad substrate specificity
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