B0Y9Z9 · 3HAO1_ASPFC

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50O2 (UniProtKB | ChEBI)
Binding site54Fe cation (UniProtKB | ChEBI); catalytic
Binding site60Fe cation (UniProtKB | ChEBI); catalytic
Binding site60substrate
Binding site102Fe cation (UniProtKB | ChEBI); catalytic
Binding site106substrate
Binding site116substrate
Binding site131a divalent metal cation (UniProtKB | ChEBI)
Binding site134a divalent metal cation (UniProtKB | ChEBI)
Binding site168a divalent metal cation (UniProtKB | ChEBI)
Binding site171a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase 1
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase 1
      (3-HAO-1
      )
    • 3-hydroxyanthranilic acid dioxygenase 1
      (HAD-1
      )
    • Biosynthesis of nicotinic acid protein 1-1

Gene names

    • Name
      bna1-1
    • ORF names
      AFUB_082850

Organism names

Accessions

  • Primary accession
    B0Y9Z9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003619761-1923-hydroxyanthranilate 3,4-dioxygenase 1

Structure

Family & Domains

Sequence similarities

Belongs to the 3-HAO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,705
  • Last updated
    2008-04-08 v1
  • Checksum
    148D406C365727F7
MLPPALNIPKWLEENSHLLQPPVNNYCVYHPSSPATAGYTVMIVGGPNARTDYHINTTPEFFYQYRGSMLLKTVDTSVSPPVFQDIPIHEGSIFLLPANTPHCPVRFKDTVGVVMEQPRPKDAVDTMLWFCKKCGEVVWEKRFVCTDLGTQVKEVVEEFAADQEKRTCKACGTIAETRYQEGEVVQPPRFLE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS499600
EMBL· GenBank· DDBJ
EDP48842.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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