B0Y473 · ALP2_ASPFC
- ProteinAlkaline protease 2
- Genealp2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Alkaline protease that allows assimilation of proteinaceous substrates. Acts as a significant virulence factor in invasive aspergillosis. Required for regular sporulation (By similarity).
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 182 | Charge relay system | |||
Active site | 214 | Charge relay system | |||
Active site | 380 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | vacuole | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | pexophagy | |
Biological Process | protein catabolic process in the vacuole | |
Biological Process | proteolysis | |
Biological Process | sporulation resulting in formation of a cellular spore |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAlkaline protease 2
- EC number
- Short namesALP2
- Alternative names
- Allergen nameAsp f 18
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionB0Y473
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Allergenic properties
Acts as a major allergen in patients suffering from extrinsic bronchial asthma. Binds to IgE.
Keywords
- Disease
Protein family/group databases
PTM/Processing
Features
Showing features for signal, propeptide, chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-16 | ||||
Propeptide | PRO_0000412302 | 17-136 | |||
Chain | PRO_0000412303 | 137-495 | Alkaline protease 2 | ||
Glycosylation | 284 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 447 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 460 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-136 | Inhibitor I9 | |||
Domain | 146-452 | Peptidase S8 | |||
Sequence similarities
Belongs to the peptidase S8 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length495
- Mass (Da)52,640
- Last updated2008-04-08 v1
- ChecksumA358FE8D6EE533D2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS499597 EMBL· GenBank· DDBJ | EDP51664.1 EMBL· GenBank· DDBJ | Genomic DNA |