B0X1V5 · MOC2B_CULQU
- ProteinMolybdopterin synthase catalytic subunit
- GeneMocs2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids157 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
Miscellaneous
This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
Catalytic activity
- 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H+
Pathway
Cofactor biosynthesis; molybdopterin biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 103-104 | substrate | |||
Binding site | 119 | substrate | |||
Binding site | 126-128 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | molybdopterin synthase complex | |
Molecular Function | molybdopterin synthase activity | |
Biological Process | Mo-molybdopterin cofactor biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMolybdopterin synthase catalytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Culicini > Culex > Culex
Accessions
- Primary accessionB0X1V5
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000369332 | 1-157 | Molybdopterin synthase catalytic subunit | ||
Interaction
Subunit
Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the MoaE family. MOCS2B subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length157
- Mass (Da)17,770
- Last updated2009-04-14 v2
- Checksum6F9E73D3D74B953F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1S4K0N1 | A0A1S4K0N1_CULQU | 6046412 | 243 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS232271 EMBL· GenBank· DDBJ | EDS38833.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |