B0VEX2 · B0VEX2_CLOAI
- ProteinDNA repair protein RadA
- GeneradA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids444 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent DNA damage sensor activity | |
Molecular Function | damaged DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | peptidase activity | |
Biological Process | proteolysis | |
Biological Process | recombinational repair |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameDNA repair protein RadA
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Candidatus Cloacimonadota > Candidatus Cloacimonadia > Candidatus Cloacimonadales > Candidatus Cloacimonadaceae > Candidatus Cloacimonas
Accessions
- Primary accessionB0VEX2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 62-211 | RecA family profile 1 | ||||
Sequence: EFSRLLTGIKEFDLVLGGGIVKGMLILIGGEPGIGKSTLMLQLSEWMGKQNKKTLYCSGEESAEQIRLRSKHLKVTSENIYLLCTNNAEHIIEAIEDNKPDLAIVDSIQSVSIPSLDALPGTVTQLRETTSRLLRTVKNLGIPLFLVGHV | ||||||
Motif | 248-252 | RadA KNRFG motif | ||||
Sequence: KNRFG | ||||||
Region | 346-444 | Lon-protease-like | ||||
Sequence: DVFVNLTGGIRSTDPSLDLAILAALISSMKDQPLIEKAVFIGEVGLNGEVRPVSQLDKHISQTLKLGYEKIFISSYAKVKANPKVVKVKDIKALYSALR |
Domain
The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.
Sequence similarities
Belongs to the RecA family. RadA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)48,869
- Last updated2008-04-08 v1
- Checksum83A9F638FEA0FF14
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU466930 EMBL· GenBank· DDBJ | CAO80593.1 EMBL· GenBank· DDBJ | Genomic DNA |