B0VEX2 · B0VEX2_CLOAI

Function

function

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site91-98ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent DNA damage sensor activity
Molecular Functiondamaged DNA binding
Molecular Functionmetal ion binding
Molecular Functionpeptidase activity
Biological Processproteolysis
Biological Processrecombinational repair

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA repair protein RadA

Gene names

    • Name
      radA
    • Ordered locus names
      CLOAM0710

Organism names

  • Taxonomic identifier
  • Strain
    • Evry
  • Taxonomic lineage
    Bacteria > Candidatus Cloacimonadota > Candidatus Cloacimonadia > Candidatus Cloacimonadales > Candidatus Cloacimonadaceae > Candidatus Cloacimonas

Accessions

  • Primary accession
    B0VEX2

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif, region.

TypeIDPosition(s)Description
Domain62-211RecA family profile 1
Motif248-252RadA KNRFG motif
Region346-444Lon-protease-like

Domain

The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

Sequence similarities

Belongs to the RecA family. RadA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    444
  • Mass (Da)
    48,869
  • Last updated
    2008-04-08 v1
  • Checksum
    83A9F638FEA0FF14
MATIFFCTECGFETGKWSGKCPACGAWGTLKESTRVTGKNNKPVETLPLSKPERIIDLEYDEFSRLLTGIKEFDLVLGGGIVKGMLILIGGEPGIGKSTLMLQLSEWMGKQNKKTLYCSGEESAEQIRLRSKHLKVTSENIYLLCTNNAEHIIEAIEDNKPDLAIVDSIQSVSIPSLDALPGTVTQLRETTSRLLRTVKNLGIPLFLVGHVTKEGLVAGPKIIEHMVDTVLYFEGEQRSQYKILRAVKNRFGSTNEIGLFEMTHLGLIEVSNPNNIFLSHEQNNIGTAISCIMEGSRSFIVEVQTLVNASNYGTPQRVAVGLDQKKLAMLLAILEKNLSLYLRNCDVFVNLTGGIRSTDPSLDLAILAALISSMKDQPLIEKAVFIGEVGLNGEVRPVSQLDKHISQTLKLGYEKIFISSYAKVKANPKVVKVKDIKALYSALR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU466930
EMBL· GenBank· DDBJ
CAO80593.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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