B0V1P1 · MC4R_DANRE
- ProteinMelanocortin receptor 4
- Genemc4r
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | melanocortin receptor activity | |
Molecular Function | melanocyte-stimulating hormone receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | energy homeostasis | |
Biological Process | energy reserve metabolic process | |
Biological Process | negative regulation of feeding behavior | |
Biological Process | regulation of growth | |
Biological Process | regulation of metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMelanocortin receptor 4
- Short namesMC4-R
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB0V1P1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-46 | Extracellular | ||||
Sequence: MNTSHHHGLHHSFRNHSQGALPVGKPSHGDRGSASGCYEQLLISTE | ||||||
Transmembrane | 47-67 | Helical; Name=1 | ||||
Sequence: IFLTLGLVSLLENILVIAAIV | ||||||
Topological domain | 68-71 | Cytoplasmic | ||||
Sequence: KNKN | ||||||
Transmembrane | 72-92 | Helical; Name=2 | ||||
Sequence: LHSPMYFFICSLAVADLLVSV | ||||||
Topological domain | 93-121 | Extracellular | ||||
Sequence: SNASETVVMALITGGNLTNRESIIKNMDN | ||||||
Transmembrane | 122-142 | Helical; Name=3 | ||||
Sequence: VFDSMICSSLLASIWSLLAIA | ||||||
Topological domain | 143-163 | Cytoplasmic | ||||
Sequence: VDRYITIFYALRYHNIMTQRR | ||||||
Transmembrane | 164-184 | Helical; Name=4 | ||||
Sequence: AGTIITCIWTFCTVSGVLFIV | ||||||
Topological domain | 185-190 | Extracellular | ||||
Sequence: YSESTT | ||||||
Transmembrane | 191-211 | Helical; Name=5 | ||||
Sequence: VLICLISMFFTMLALMASLYV | ||||||
Topological domain | 212-246 | Cytoplasmic | ||||
Sequence: HMFLLARLHMKRIAALPGNGPIWQAANMKGAITIT | ||||||
Transmembrane | 247-267 | Helical; Name=6 | ||||
Sequence: ILLGVFVVCWAPFFLHLILMI | ||||||
Topological domain | 268-281 | Extracellular | ||||
Sequence: SCPRNPYCVCFMSH | ||||||
Transmembrane | 282-302 | Helical; Name=7 | ||||
Sequence: FNMYLILIMCNSVIDPLIYAF | ||||||
Topological domain | 303-326 | Cytoplasmic | ||||
Sequence: RSQEMRKTFKEICCCWYGLASLCV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000424026 | 1-326 | Melanocortin receptor 4 | |||
Sequence: MNTSHHHGLHHSFRNHSQGALPVGKPSHGDRGSASGCYEQLLISTEIFLTLGLVSLLENILVIAAIVKNKNLHSPMYFFICSLAVADLLVSVSNASETVVMALITGGNLTNRESIIKNMDNVFDSMICSSLLASIWSLLAIAVDRYITIFYALRYHNIMTQRRAGTIITCIWTFCTVSGVLFIVYSESTTVLICLISMFFTMLALMASLYVHMFLLARLHMKRIAALPGNGPIWQAANMKGAITITILLGVFVVCWAPFFLHLILMISCPRNPYCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEICCCWYGLASLCV | ||||||
Glycosylation | 2 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 15 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 81 | Interchain | ||||
Sequence: C | ||||||
Glycosylation | 94 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 108 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 316 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer; disulfide-linked, also forms higher order oligomers (By similarity).
Interacts with mrap2a; decreasing ligand-sensitivity. Interacts with mrap2b; increasing ligand-sensitivity and generation of cAMP
Interacts with mrap2a; decreasing ligand-sensitivity. Interacts with mrap2b; increasing ligand-sensitivity and generation of cAMP
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-31 | Disordered | ||||
Sequence: MNTSHHHGLHHSFRNHSQGALPVGKPSHGDR |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)36,435
- Last updated2008-04-08 v1
- Checksum40680015C2430C8E
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 47 | in Ref. 1; AAL85494, 2; AAO24745 and 4; AAI63227/AAI63219 | ||||
Sequence: I → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY078989 EMBL· GenBank· DDBJ | AAL85494.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY161850 EMBL· GenBank· DDBJ | AAO24745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR925777 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC163219 EMBL· GenBank· DDBJ | AAI63219.1 EMBL· GenBank· DDBJ | mRNA | ||
BC163227 EMBL· GenBank· DDBJ | AAI63227.1 EMBL· GenBank· DDBJ | mRNA |