B0V1P1 · MC4R_DANRE

Function

function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functionmelanocortin receptor activity
Molecular Functionmelanocyte-stimulating hormone receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processenergy homeostasis
Biological Processenergy reserve metabolic process
Biological Processnegative regulation of feeding behavior
Biological Processregulation of growth
Biological Processregulation of metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Melanocortin receptor 4
  • Short names
    MC4-R

Gene names

    • Name
      mc4r

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    B0V1P1
  • Secondary accessions
    • Q8JGW3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-46Extracellular
Transmembrane47-67Helical; Name=1
Topological domain68-71Cytoplasmic
Transmembrane72-92Helical; Name=2
Topological domain93-121Extracellular
Transmembrane122-142Helical; Name=3
Topological domain143-163Cytoplasmic
Transmembrane164-184Helical; Name=4
Topological domain185-190Extracellular
Transmembrane191-211Helical; Name=5
Topological domain212-246Cytoplasmic
Transmembrane247-267Helical; Name=6
Topological domain268-281Extracellular
Transmembrane282-302Helical; Name=7
Topological domain303-326Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00004240261-326Melanocortin receptor 4
Glycosylation2N-linked (GlcNAc...) asparagine
Glycosylation15N-linked (GlcNAc...) asparagine
Disulfide bond81Interchain
Glycosylation94N-linked (GlcNAc...) asparagine
Glycosylation108N-linked (GlcNAc...) asparagine
Lipidation316S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked, also forms higher order oligomers (By similarity).
Interacts with mrap2a; decreasing ligand-sensitivity. Interacts with mrap2b; increasing ligand-sensitivity and generation of cAMP

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-31Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    36,435
  • Last updated
    2008-04-08 v1
  • Checksum
    40680015C2430C8E
MNTSHHHGLHHSFRNHSQGALPVGKPSHGDRGSASGCYEQLLISTEIFLTLGLVSLLENILVIAAIVKNKNLHSPMYFFICSLAVADLLVSVSNASETVVMALITGGNLTNRESIIKNMDNVFDSMICSSLLASIWSLLAIAVDRYITIFYALRYHNIMTQRRAGTIITCIWTFCTVSGVLFIVYSESTTVLICLISMFFTMLALMASLYVHMFLLARLHMKRIAALPGNGPIWQAANMKGAITITILLGVFVVCWAPFFLHLILMISCPRNPYCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEICCCWYGLASLCV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict47in Ref. 1; AAL85494, 2; AAO24745 and 4; AAI63227/AAI63219

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY078989
EMBL· GenBank· DDBJ
AAL85494.1
EMBL· GenBank· DDBJ
Genomic DNA
AY161850
EMBL· GenBank· DDBJ
AAO24745.1
EMBL· GenBank· DDBJ
Genomic DNA
CR925777
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC163219
EMBL· GenBank· DDBJ
AAI63219.1
EMBL· GenBank· DDBJ
mRNA
BC163227
EMBL· GenBank· DDBJ
AAI63227.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp