B0UYH6 · RPAP2_DANRE

Function

function

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).
Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site94Zn2+ (UniProtKB | ChEBI)
Binding site99Zn2+ (UniProtKB | ChEBI)
Binding site130Zn2+ (UniProtKB | ChEBI)
Binding site134Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componenttranscription preinitiation complex
Molecular Functionmetal ion binding
Molecular Functionmyosin phosphatase activity
Molecular Functionprotein serine/threonine phosphatase activity
Molecular FunctionRNA polymerase core enzyme binding
Molecular FunctionRNA polymerase II CTD heptapeptide repeat phosphatase activity
Biological ProcessPERK-mediated unfolded protein response
Biological ProcesssnRNA transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative RNA polymerase II subunit B1 CTD phosphatase rpap2
  • EC number
  • Alternative names
    • RNA polymerase II-associated protein 2

Gene names

    • Name
      rpap2
    • ORF names
      si:dkey-63k7.3

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    B0UYH6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004162891-601Putative RNA polymerase II subunit B1 CTD phosphatase rpap2

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Associates with the RNA polymerase II complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, zinc finger, compositional bias.

TypeIDPosition(s)Description
Region1-36Disordered
Coiled coil24-62
Zinc finger71-154RTR1-type
Region221-278Disordered
Compositional bias228-259Basic and acidic residues
Compositional bias297-315Polar residues
Region297-317Disordered

Sequence similarities

Belongs to the RPAP2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    67,549
  • Last updated
    2008-04-08 v1
  • Checksum
    78093E0ED1C0A82F
MDAGEVTRKSRPSKSKKKGGKGTQAISAEDEAKRREAVKEQLRQKLELERKARQVVERLLEDSVTEEFLMDCAWHITPANYKDTVEERSIAKLCGYPMCPNKLTNVPTQQYKISTKTNKVYDITERKCFCSNFCYKASKSFELQISKIPLWLRKEESPPEIKLMKQGDGGSSGQEIKLIDKPITEADIDNPIEDIPESNKDLIQGENGDIEQDFVSSVVSNQHKQVHWGKLPKRDEVSEDAAEYSHSEHEQRINGENKDESESSQTPQPQKDTTDHPALEKNASEIEGTLELLNQDKSTQQEGENTSSSQPESDISVPVAGDLNITQVGMSKRSAAGLKGLLKDHHKAKTASTAISQCLLERLRQAFIEWRTKETMIFLYGPDYASGMQLSTAGAWEEEQLDEDDLDEAEVGVRSAEGGPSRTSAPVPDVETLRKETEMLELRVREFYKGVCVLPEEVETAAVKETEHTQDSGKDPPLPLVDSHAQHQIQKRIVVEKLSHSLRDIVGPLRLTMSDVINDVNNLVRTFRFTNTNIIHKSPEWTLIAVVLLSVLTEVSPLLRESLASVSSLEYISCFMKELKLEDKDLHNLVLLFKPCVPIQT

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M1N6W7A0A8M1N6W7_DANRErpap2324
A0A8M2BIG0A0A8M2BIG0_DANRErpap2528

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias228-259Basic and acidic residues
Compositional bias297-315Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR450845
EMBL· GenBank· DDBJ
CAQ13680.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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