B0UYH6 · RPAP2_DANRE
- ProteinPutative RNA polymerase II subunit B1 CTD phosphatase rpap2
- Generpap2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids601 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).
Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).
Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).
Catalytic activity
- H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | transcription preinitiation complex | |
Molecular Function | metal ion binding | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein serine/threonine phosphatase activity | |
Molecular Function | RNA polymerase core enzyme binding | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat phosphatase activity | |
Biological Process | PERK-mediated unfolded protein response | |
Biological Process | snRNA transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative RNA polymerase II subunit B1 CTD phosphatase rpap2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB0UYH6
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416289 | 1-601 | Putative RNA polymerase II subunit B1 CTD phosphatase rpap2 | |||
Sequence: MDAGEVTRKSRPSKSKKKGGKGTQAISAEDEAKRREAVKEQLRQKLELERKARQVVERLLEDSVTEEFLMDCAWHITPANYKDTVEERSIAKLCGYPMCPNKLTNVPTQQYKISTKTNKVYDITERKCFCSNFCYKASKSFELQISKIPLWLRKEESPPEIKLMKQGDGGSSGQEIKLIDKPITEADIDNPIEDIPESNKDLIQGENGDIEQDFVSSVVSNQHKQVHWGKLPKRDEVSEDAAEYSHSEHEQRINGENKDESESSQTPQPQKDTTDHPALEKNASEIEGTLELLNQDKSTQQEGENTSSSQPESDISVPVAGDLNITQVGMSKRSAAGLKGLLKDHHKAKTASTAISQCLLERLRQAFIEWRTKETMIFLYGPDYASGMQLSTAGAWEEEQLDEDDLDEAEVGVRSAEGGPSRTSAPVPDVETLRKETEMLELRVREFYKGVCVLPEEVETAAVKETEHTQDSGKDPPLPLVDSHAQHQIQKRIVVEKLSHSLRDIVGPLRLTMSDVINDVNNLVRTFRFTNTNIIHKSPEWTLIAVVLLSVLTEVSPLLRESLASVSSLEYISCFMKELKLEDKDLHNLVLLFKPCVPIQT |
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, coiled coil, zinc finger, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MDAGEVTRKSRPSKSKKKGGKGTQAISAEDEAKRRE | ||||||
Coiled coil | 24-62 | |||||
Sequence: QAISAEDEAKRREAVKEQLRQKLELERKARQVVERLLED | ||||||
Zinc finger | 71-154 | RTR1-type | ||||
Sequence: DCAWHITPANYKDTVEERSIAKLCGYPMCPNKLTNVPTQQYKISTKTNKVYDITERKCFCSNFCYKASKSFELQISKIPLWLRK | ||||||
Region | 221-278 | Disordered | ||||
Sequence: NQHKQVHWGKLPKRDEVSEDAAEYSHSEHEQRINGENKDESESSQTPQPQKDTTDHPA | ||||||
Compositional bias | 228-259 | Basic and acidic residues | ||||
Sequence: WGKLPKRDEVSEDAAEYSHSEHEQRINGENKD | ||||||
Compositional bias | 297-315 | Polar residues | ||||
Sequence: KSTQQEGENTSSSQPESDI | ||||||
Region | 297-317 | Disordered | ||||
Sequence: KSTQQEGENTSSSQPESDISV |
Sequence similarities
Belongs to the RPAP2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)67,549
- Last updated2008-04-08 v1
- Checksum78093E0ED1C0A82F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M1N6W7 | A0A8M1N6W7_DANRE | rpap2 | 324 | ||
A0A8M2BIG0 | A0A8M2BIG0_DANRE | rpap2 | 528 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 228-259 | Basic and acidic residues | ||||
Sequence: WGKLPKRDEVSEDAAEYSHSEHEQRINGENKD | ||||||
Compositional bias | 297-315 | Polar residues | ||||
Sequence: KSTQQEGENTSSSQPESDI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR450845 EMBL· GenBank· DDBJ | CAQ13680.1 EMBL· GenBank· DDBJ | Genomic DNA |