B0UXN0 · B0UXN0_DANRE
- ProteinSulfhydryl oxidase
- Geneqsox1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids778 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Catalytic activity
- 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Molecular Function | flavin-dependent sulfhydryl oxidase activity | |
Molecular Function | protein disulfide isomerase activity | |
Biological Process | protein folding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfhydryl oxidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB0UXN0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-44 | Helical | ||||
Sequence: FYSFLCAFITCVSLCPVLCEAGLY | ||||||
Transmembrane | 747-764 | Helical | ||||
Sequence: VLLYLLSTMCLLAMYMYF |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-164 | Thioredoxin | ||||
Sequence: YTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFSPVWKSLARDIKEWKPAVDLAAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSRDVRGLRQYIIENLE | ||||||
Domain | 407-510 | ERV/ALR sulfhydryl oxidase | ||||
Sequence: SQARYRGYPCAVWTLFHVLTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPCATHFEAMAAESMDQVNSLSGAVIWLWSRHNRVNNRLAGDLSEDPHFPKIQW | ||||||
Compositional bias | 569-592 | Basic and acidic residues | ||||
Sequence: AARMEKEAGRGADRRARDIFDNNP | ||||||
Region | 569-644 | Disordered | ||||
Sequence: AARMEKEAGRGADRRARDIFDNNPADEPQEEEEEEEEEEPTFEEQAVEPYPAGLEGAPGADQAPWEKPQPLSSQRK | ||||||
Compositional bias | 593-612 | Acidic residues | ||||
Sequence: ADEPQEEEEEEEEEEPTFEE |
Sequence similarities
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length778
- Mass (Da)88,047
- Last updated2008-04-08 v1
- Checksum9895990B3802EF79
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 569-592 | Basic and acidic residues | ||||
Sequence: AARMEKEAGRGADRRARDIFDNNP | ||||||
Compositional bias | 593-612 | Acidic residues | ||||
Sequence: ADEPQEEEEEEEEEEPTFEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR381643 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |