B0UXN0 · B0UXN0_DANRE

Function

function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Molecular Functionflavin-dependent sulfhydryl oxidase activity
Molecular Functionprotein disulfide isomerase activity
Biological Processprotein folding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfhydryl oxidase
  • EC number

Gene names

    • Name
      qsox1
    • Synonyms
      fk65c10
      , im:6793551
      , sb:cb840
      , si:dkey-39n1.2
      , wu:fc30g09
      , wu:fk65c10

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    B0UXN0
  • Secondary accessions
    • A0A8M1NHY3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-44Helical
Transmembrane747-764Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain44-164Thioredoxin
Domain407-510ERV/ALR sulfhydryl oxidase
Compositional bias569-592Basic and acidic residues
Region569-644Disordered
Compositional bias593-612Acidic residues

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    778
  • Mass (Da)
    88,047
  • Last updated
    2008-04-08 v1
  • Checksum
    9895990B3802EF79
MARRGCGATSCYTTKTKLNSFYSFLCAFITCVSLCPVLCEAGLYTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFSPVWKSLARDIKEWKPAVDLAAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSRDVRGLRQYIIENLELHTEAWPPACPPLETASEAEVHHFFPANNVKYLALVFENKKSYVGREVTLDLLQYENIAVRRVLDTETNLVSRFGVTEFPSCYLYDSSGNITRLKVLKEARTFYSYALQRLPGVVRTGKHQTPITELIKNSTLQEWRPFNKSRVYMSDLESALHYSLRVELSSHTSISGDDLIALKKYINVLAKYFPGRPSVKSALQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTSDAVLPEGVQWVGCQGSQARYRGYPCAVWTLFHVLTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPCATHFEAMAAESMDQVNSLSGAVIWLWSRHNRVNNRLAGDLSEDPHFPKIQWPSPELCPSCHGVTIIGDHNWIKDEVPQFLQNYFSSSRILNDYLQDETQALIQQRNRLTAARMEKEAGRGADRRARDIFDNNPADEPQEEEEEEEEEEPTFEEQAVEPYPAGLEGAPGADQAPWEKPQPLSSQRKPKIVGMKLREAQEDIVDLDYFVSQHYKAKALRAAAMSGVVRRRSLQKKEDVEDLQFEGGWRVKRDLGSQEENFGIEPYPRAQSKHWMSLLSVGFSRLDVSLCVLLYLLSTMCLLAMYMYFKLRIKLRSAKVSLP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias569-592Basic and acidic residues
Compositional bias593-612Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR381643
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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