B0TG92 · THIG_HELMI

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

125520406080100120140160180200220240
Type
IDPosition(s)Description
Active site96Schiff-base intermediate with DXP
Binding site1571-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site183-1841-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site205-2061-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionthiazole synthase activity
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG
    • ORF names
      HM1_2031
    • Ordered locus names
      Helmi_19630

Organism names

Accessions

  • Primary accession
    B0TG92

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001968681-255Thiazole synthase

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ThiG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    255
  • Mass (Da)
    26,925
  • Last updated
    2008-04-08 v1
  • Checksum
    2F3AE877757CEF5F
MDRLVIGGRELKNRLFIGSGKFADERVIRDIVAQTGVEVVTVALRRVSLSGDGENILHCIPKECVLLPNTSGARTAEEAIRIARLARAAGCGNWVKIEVISDNKYLLPDNNETIKATGVLAEEGFVVLPYMHPDLYAAKELERAGAAAVMPLGAPIGTNRGLKTKEIVRILIEECSVPVIVDAGIGKPSEAAEAMEMGAAACLVNTAIATAGDPLVMARAFSQAVAAGRLAYLAQPGERTEYARASSPLTGFLGS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000930
EMBL· GenBank· DDBJ
ABZ84588.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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