B0STV8 · SPEE_LEPBP
- ProteinPolyamine aminopropyltransferase
- GenespeE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids281 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity
- putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H+ + S-methyl-5'-thioadenosine + spermidine
Pathway
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 33 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 64 | spermidine (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 88 | spermidine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 108 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 139-140 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Active site | 157 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 157-160 | spermidine (UniProtKB | ChEBI) | ||||
Sequence: DSSD | ||||||
Binding site | 164 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: P |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | spermidine synthase activity | |
Biological Process | spermidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyamine aminopropyltransferase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionB0STV8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000099292 | 1-281 | Polyamine aminopropyltransferase | |||
Sequence: MEIWYTEKLELEKGRAVSYRVTKTIESLQSPFQKIDIFETQSFGRMFTLDGVTMVTNKDEHSYHEMIAHIPMMSHPNPESVLVIGGGDGGTVREVLKHPSVKEVVLCEIDKAVVDISYKYFPECADAMKDPKVIHHYDDGAKFARDNKGRFDVILVDSSDPVGPAEVLFKEPFFRDMASALKPTGIIATQAESFWYHGDVITSLFEFIPKIFPEYGYYYTTIPTYPSGIIGFTFLSNAIDPYAVTPDPKRVPKGLKYYSPEIHKAAFVLPEFAKAYIKRKG |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-237 | PABS | ||||
Sequence: EIWYTEKLELEKGRAVSYRVTKTIESLQSPFQKIDIFETQSFGRMFTLDGVTMVTNKDEHSYHEMIAHIPMMSHPNPESVLVIGGGDGGTVREVLKHPSVKEVVLCEIDKAVVDISYKYFPECADAMKDPKVIHHYDDGAKFARDNKGRFDVILVDSSDPVGPAEVLFKEPFFRDMASALKPTGIIATQAESFWYHGDVITSLFEFIPKIFPEYGYYYTTIPTYPSGIIGFTFLSN |
Sequence similarities
Belongs to the spermidine/spermine synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)31,816
- Last updated2008-04-08 v1
- ChecksumA3DDEB7CBBEBE8A5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000787 EMBL· GenBank· DDBJ | ABZ99642.1 EMBL· GenBank· DDBJ | Genomic DNA |