B0LPF3 · B0LPF3_HUMAN

  • Protein
    Growth factor receptor-bound protein 2
  • Gene
    GRB2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcell-cell junction
Cellular ComponentCOP9 signalosome
Cellular Componentcytosol
Cellular Componentendosome
Cellular ComponentGolgi apparatus
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Cellular Componentvesicle membrane
Molecular Functionephrin receptor binding
Molecular Functionguanyl-nucleotide exchange factor adaptor activity
Molecular Functionprotein domain specific binding
Molecular Functionprotein phosphatase binding
Molecular Functiontransmembrane receptor protein tyrosine kinase adaptor activity
Biological ProcessB cell receptor signaling pathway
Biological Processbranching involved in labyrinthine layer morphogenesis
Biological Processendodermal cell differentiation
Biological Processepidermal growth factor receptor signaling pathway
Biological Processfibroblast growth factor receptor signaling pathway
Biological Processinsulin receptor signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processmyelination
Biological Processpositive regulation of actin filament polymerization
Biological Processregulation of MAPK cascade
Biological ProcessSchwann cell development

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Growth factor receptor-bound protein 2
    • cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA

Gene names

    • Name
      GRB2
    • ORF names
      hCG_27179

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B0LPF3

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-58SH3
Domain60-152SH2
Domain156-215SH3

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    217
  • Mass (Da)
    25,206
  • Last updated
    2008-03-18 v1
  • Checksum
    83A4B0BA1B248DC4
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU332843
EMBL· GenBank· DDBJ
ABY87532.1
EMBL· GenBank· DDBJ
Genomic DNA
JX512444
EMBL· GenBank· DDBJ
AGC09591.1
EMBL· GenBank· DDBJ
Genomic DNA
AK315565
EMBL· GenBank· DDBJ
BAG37940.1
EMBL· GenBank· DDBJ
mRNA
CH471099
EMBL· GenBank· DDBJ
EAW89270.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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