B0JFT3 · LSPA_MICAN

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

115520406080100120140
TypeIDPosition(s)Description
Active site117
Active site133

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • Ordered locus names
      MAE_00150

Organism names

Accessions

  • Primary accession
    B0JFT3

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane39-59Helical
Transmembrane63-83Helical
Transmembrane96-116Helical
Transmembrane126-146Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000972661-155Lipoprotein signal peptidase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    155
  • Mass (Da)
    17,625
  • Last updated
    2008-03-18 v1
  • Checksum
    D75614392C075BBE
MFKKNRWFWIVAVIGLILDQVTKYITVQSFEQIGDTFPIIPGVFHFTYVINTGAAFSAFRGGVGWLKWLSLLVSLGLMAFAYFGPHLNRWEQLAYGFILAGAFGNGIDRFLFGYVVDFLDFRLINFPVFNLADVFINIGIICLLISTFPHKSRVP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP009552
EMBL· GenBank· DDBJ
BAF99836.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp